Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

• Published in: Clinical orthopaedics and related research Vol. 469; no. 10; pp. 2874 - 2880
• Main Authors: Charoencholvanich, Keerati, Siriwattanasakul, Pichet
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.10.2011; Springer; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Administration, Oral; Aged; Antifibrinolytic Agents - administration & dosage; Arthroplasty, Replacement, Knee - adverse effects; Biological and medical sciences; Biomarkers - blood; Blood Transfusion; Chi-Square Distribution; Clinical Research; Conservative Orthopedics; Diseases of the osteoarticular system; Double-Blind Method; Drug Administration Schedule; Female; Hemoglobins - metabolism; Humans; Injections, Intravenous; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Orthopedic surgery; Orthopedics; Osteoarthritis, Knee - surgery; Postoperative Hemorrhage - blood; Postoperative Hemorrhage - etiology; Postoperative Hemorrhage - prevention & control; Prospective Studies; Risk Assessment; Risk Factors; Sports Medicine; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Orthopedics; Thailand; Time Factors; Tranexamic Acid - administration & dosage; Transfusion Reaction; Treatment Outcome; Allogenic Blood Transfusion; Reduce Blood Loss; Tranexamic Acid; Postoperative Blood Loss; Preoperative Hemoglobin; Knee; Transfusion; Hemostatic; Prosthesis; Orthopedics; Blood loss; Tranexamic acid; Antifibrinolytic; Blood

Background TKA may be associated with considerable blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission. Blood transfusion also involves additional cost, therefore a reduction in its use is important. Several methods reportedly reduce postoperative bl...