Envelope stress responses defend against type six secretion system attacks independently of immunity proteins

• Published in: Nature microbiology Vol. 5; no. 5; pp. 706 - 714
• Main Authors: Hersch, Steven J., Watanabe, Nobuhiko, Stietz, Maria Silvina, Manera, Kevin, Kamal, Fatima, Burkinshaw, Brianne, Lam, Linh, Pun, Alexander, Li, Meixin, Savchenko, Alexei, Dong, Tao G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 14/63; 38/90; 45/77; 631/326/2565; 631/326/41/2180; 631/326/41/2482; 631/326/41/2529; 82/80; 82/83; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biomedical and Life Sciences; Defense; E coli; Endopeptidase; Escherichia coli - genetics; Escherichia coli - metabolism; Gene Expression Regulation, Bacterial; Gram-negative bacteria; Immunity - genetics; Infectious Diseases; Life Sciences; Medical Microbiology; Microbiology; Models, Molecular; Parasitology; Protein Conformation; Proteins; Species; Toxicity; Type VI Secretion Systems - chemistry; Type VI Secretion Systems - genetics; Type VI Secretion Systems - immunology; Type VI Secretion Systems - metabolism; Vibrio cholerae - genetics; Vibrio cholerae - metabolism; Virology; Virulence - genetics

The arms race among microorganisms is a key driver in the evolution of not only the weapons but also defence mechanisms. Many Gram-negative bacteria use the type six secretion system (T6SS) to deliver toxic effectors directly into neighbouring cells. Defence against effectors requires cognate immuni...