Identification and metabolic characteristics of an apolipoprotein C-II variant isolated from a hypertriglyceridemic subject

• Published in: Journal of lipid research Vol. 31; no. 3; pp. 385 - 396
• Main Authors: Huff, MW, Evans, AJ, Wolfe, BM, Connelly, PW, Maguire, GF, Strong, WL
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.1990; Elsevier
• Subjects: Adult; Apolipoprotein C-II; Apolipoproteins B - blood; Apolipoproteins C - blood; Apolipoproteins C - isolation & purification; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Heparin - administration & dosage; Humans; Hypertriglyceridemia - blood; Isoelectric Focusing; Lipoprotein Lipase - blood; Lipoproteins, VLDL - blood; Male; Peptide Fragments; Peptide Mapping; Triglycerides - blood

The very low density lipoprotein (VLDL) apolipoproteins from a Type IV hypertriglyceridemic Caucasian subject (plasma TG: 645 mg/dl) and his brother (plasma TG: 328 mg/dl) were separated by isoelectric focusing gel electrophoresis (IEF) and found to contain two isoforms of apoC-II, identified by imm...