Expression of urokinase type plasminogen activator receptor (uPAR) in the bovine oviduct: Relationship with uPA effect on oviductal epithelial cells

• Published in: Research in veterinary science Vol. 97; no. 1; pp. 118 - 123
• Main Authors: García, D.C., Miceli, D.C., Valdecantos, P.A., García, E.V., Roldán-Olarte, M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2014; Elsevier Limited
• Subjects: Analysis of Variance; Animals; Bovine; c-fos; Cattle; Cell culture; Cells, Cultured; Cellular Microenvironment; Culture; Embryos; Epithelial Cells - metabolism; Estrous Cycle - metabolism; Fallopian Tubes - cytology; Fallopian Tubes - metabolism; Female; Gene expression; Immunohistochemistry; Oligonucleotides - genetics; Oviduct; Proteins; Proto-Oncogene Proteins c-fos - metabolism; Real-Time Polymerase Chain Reaction; Receptors, Urokinase Plasminogen Activator - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Rodents; Signal Transduction - physiology; Transcription factors; uPA; uPAR; Urokinase-Type Plasminogen Activator - metabolism; Veterinary medicine; c-fos; uPAR; Oviduct; Bovine; Culture; uPA

•uPAR and uPA are expressed in bovine oviduct during the estrous cycle.•uPAR localizes at the apical zone of epithelial cells in vivo and in vitro.•uPA stimulation increases c-fos expression in oviductal cell cultures.•uPA/uPAR binding would activate signaling pathways regulating oviductal function....