Increased Circulating Cathepsin L in Patients with Coronary Artery Disease

• Published in: International Heart Journal Vol. 62; no. 1; pp. 9 - 15
• Main Authors: Yu, Chenglin, Xu, Wenhu, Cheng, Xianwu, Jiang, Haiying, Wan, Ying, Zhang, Shengming, Xin, Minglong, Jin, Xiongjie
• Format: Journal Article
• Language: English
• Published: Japan International Heart Journal Association 30.01.2021; Japan Science and Technology Agency
• Subjects: Acute Coronary Syndrome - blood; Adult; Aged; Angina; Angina pectoris; Angina, Stable - blood; Angiography; Arteriosclerosis; Atherosclerosis - blood; Atherosclerosis - physiopathology; Biomarker; Biomarkers - blood; C-reactive protein; C-Reactive Protein - metabolism; Cardiovascular disease; Case-Control Studies; Cathepsin L; Cathepsin L - metabolism; China - epidemiology; Cholesterol; Collagen (type I); Collagenase; Coronary Angiography - methods; Coronary artery; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - epidemiology; Coronary Artery Disease - surgery; Coronary vessels; Cysteine protease; Female; Heart diseases; High-sensitive C-reactive protein; Humans; Ischemic heart disease; Lipoproteins, HDL - blood; Male; Middle Aged; Percutaneous Coronary Intervention - methods; Plasma; Prevalence; China; Ischemic heart disease; Biomarker; High-sensitive C-reactive protein; Cysteine protease
• ISSN: 1349-2365; 1349-3299
• DOI: 10.1536/ihj.20-182

Cathepsin L (CatL) is a potent collagenase involved in atherosclerotic vascular remodeling and dysfunction in animals and humans. This study investigated the hypothesis that plasma CatL is associated with the prevalence of coronary artery disease (CAD). Between February May 2011 and January 2013, 20...