Carotid intima media thickness in patients with sporadic idiopathic hypoparathyroidism: a pilot study

Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phos...

Full description

Saved in:
Bibliographic Details
Published inEndocrine Journal Vol. 59; no. 7; pp. 555 - 559
Main Authors Gupta, Yashdeep, Bhadada, Sanjay Kumar, Kalara, Naveen, Khurana, Dhiraj, Jain, Sanjay, Bhansali, Anil, Upreti, Vimal, Shah, Viral N
Format Journal Article
LanguageEnglish
Published Japan The Japan Endocrine Society 2012
Subjects
Adolescent
Adult
Calcium - blood
Calcium - metabolism
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Cardiovascular risk
Carotid Intima-Media Thickness
Case-Control Studies
Child
Female
Humans
Hypoparathyroidism
Hypoparathyroidism - complications
Hypoparathyroidism - diagnostic imaging
Hypoparathyroidism - physiopathology
Male
Middle Aged
Parathyroid Hormone - blood
Parathyroid Hormone - metabolism
Pilot Projects
Risk Factors
Young Adult
Online AccessGet full text
ISSN0918-8959
1348-4540
1348-4540
DOI10.1507/endocrj.EJ11-0400

Cover

Abstract Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phosphate levels and hence, we planned this case-control study. In this study, we compared CIMT in 18 consecutive patients of SIH, with age and sex matched healthy subjects. CIMT was measured by B-mode ultrasonography by a single trained operator blinded to subject’s details. CIMT values in patients with SIH were significantly higher than healthy subjects (0.63±0.06 mm vs 0.47±0.07mm, p<0.001). Despite, healthy subjects had higher body mass index, higher low density lipoprotein cholesterol and fasting plasma glucose, CIMT was higher in subjects with SIH. Neither clinical nor biochemical parameters correlated with CIMT in patients with SIH except age. In conclusion, sporadic idiopathic hypoparathyroidism is associated with increased CIMT but biochemical parameters do not correlate with CIMT.
AbstractList Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phosphate levels and hence, we planned this case-control study. In this study, we compared CIMT in 18 consecutive patients of SIH, with age and sex matched healthy subjects. CIMT was measured by B-mode ultrasonography by a single trained operator blinded to subject's details. CIMT values in patients with SIH were significantly higher than healthy subjects (0.63 ± 0.06 mm vs 0.47 ± 0.07 mm, p<0.001). Despite, healthy subjects had higher body mass index, higher low density lipoprotein cholesterol and fasting plasma glucose, CIMT was higher in subjects with SIH. Neither clinical nor biochemical parameters correlated with CIMT in patients with SIH except age. In conclusion, sporadic idiopathic hypoparathyroidism is associated with increased CIMT but biochemical parameters do not correlate with CIMT.Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phosphate levels and hence, we planned this case-control study. In this study, we compared CIMT in 18 consecutive patients of SIH, with age and sex matched healthy subjects. CIMT was measured by B-mode ultrasonography by a single trained operator blinded to subject's details. CIMT values in patients with SIH were significantly higher than healthy subjects (0.63 ± 0.06 mm vs 0.47 ± 0.07 mm, p<0.001). Despite, healthy subjects had higher body mass index, higher low density lipoprotein cholesterol and fasting plasma glucose, CIMT was higher in subjects with SIH. Neither clinical nor biochemical parameters correlated with CIMT in patients with SIH except age. In conclusion, sporadic idiopathic hypoparathyroidism is associated with increased CIMT but biochemical parameters do not correlate with CIMT.
Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phosphate levels and hence, we planned this case-control study. In this study, we compared CIMT in 18 consecutive patients of SIH, with age and sex matched healthy subjects. CIMT was measured by B-mode ultrasonography by a single trained operator blinded to subject's details. CIMT values in patients with SIH were significantly higher than healthy subjects (0.63 ± 0.06 mm vs 0.47 ± 0.07 mm, p<0.001). Despite, healthy subjects had higher body mass index, higher low density lipoprotein cholesterol and fasting plasma glucose, CIMT was higher in subjects with SIH. Neither clinical nor biochemical parameters correlated with CIMT in patients with SIH except age. In conclusion, sporadic idiopathic hypoparathyroidism is associated with increased CIMT but biochemical parameters do not correlate with CIMT.
Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information on CIMT changes is lacking in patients with sporadic idiopathic hypoparathyroidism (SIH) which is also a disorder of altered calcium and phosphate levels and hence, we planned this case-control study. In this study, we compared CIMT in 18 consecutive patients of SIH, with age and sex matched healthy subjects. CIMT was measured by B-mode ultrasonography by a single trained operator blinded to subject’s details. CIMT values in patients with SIH were significantly higher than healthy subjects (0.63±0.06 mm vs 0.47±0.07mm, p<0.001). Despite, healthy subjects had higher body mass index, higher low density lipoprotein cholesterol and fasting plasma glucose, CIMT was higher in subjects with SIH. Neither clinical nor biochemical parameters correlated with CIMT in patients with SIH except age. In conclusion, sporadic idiopathic hypoparathyroidism is associated with increased CIMT but biochemical parameters do not correlate with CIMT.
Author Bhadada, Sanjay Kumar
Jain, Sanjay
Gupta, Yashdeep
Khurana, Dhiraj
Kalara, Naveen
Upreti, Vimal
Shah, Viral N
Bhansali, Anil
Author_xml – sequence: 1
  fullname: Gupta, Yashdeep
  organization: Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Bhadada, Sanjay Kumar
  organization: Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Kalara, Naveen
  organization: Department of Radiodiagnosis, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Khurana, Dhiraj
  organization: Department of Neurology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Jain, Sanjay
  organization: Department of Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Bhansali, Anil
  organization: Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Upreti, Vimal
  organization: Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
– sequence: 1
  fullname: Shah, Viral N
  organization: Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh (UT), India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22481143$$D View this record in MEDLINE/PubMed
BookMark eNp9kMtOAyEUhompsRd9ADeGpZupMMDAuDNNrZombnRNKMNY6nQYgcb07aVpnYULN1wO33fI-cdg0LrWAHCN0RQzxO9MWzntN9P5C8YZogidgREmVGSUUTQAI1RikYmSlUMwDmGDECGMkgswzHMqMKZkBMxMeRdtBW0b7VbBramsgnFt9WdrQkhl2KloTRsD_LZxDUPnvKqshrayLj0lEq73XTr6dNl7l-phew8V7GzjIgxxV-0vwXmtmmCuTvsEvD_O32ZP2fJ18Tx7WGaaliJmOaemLHTOK6YZphUpcqqLVZ3zEglWYKWE0qzmq5UuqCgwIXnOsWJpxEKLmpMJuD327bz72pkQ5dYGbZpGtcbtgsSIIMFpyVFCb07obpWGlp1P4_u9_I0mAfgIaO9C8KbuEYzkIX55il8e4peH-JPD_zjaxhSfa6NXtvnXXBzNTYjqw_R_KR-tbkxvsFLyw9KbPaHXyieM_ABcXKb5
CitedBy_id crossref_primary_10_1111_cen_14872
crossref_primary_10_1177_0883073814544366
crossref_primary_10_20945_2359_4292_2023_0053
Cites_doi 10.1681/ASN.2004070602
10.1038/sj.ki.5001996
10.1161/01.STR.0000102044.27905.B5
10.1093/oxfordjournals.aje.a009302
10.1093/ndt/gfl395
10.1007/s00467-007-0733-6
10.1111/j.1742-1241.2008.01801.x
10.1159/000065203
10.1053/j.ajkd.2008.03.020
10.4103/0028-3886.84342
10.1053/j.ajkd.2005.02.008
10.1097/01.ASN.0000145894.57533.C4
ContentType Journal Article
Copyright The Japan Endocrine Society
Copyright_xml – notice: The Japan Endocrine Society
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1507/endocrj.EJ11-0400
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1348-4540
EndPage 559
ExternalDocumentID 22481143
10_1507_endocrj_EJ11_0400
article_endocrj_59_7_59_EJ11_0400_article_char_en
Genre Journal Article
GroupedDBID ---
.55
.GJ
29G
2WC
3O-
53G
5GY
5RE
AAEJM
AAFWJ
ACPRK
ADBBV
AENEX
AFPKN
AJJEV
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BKOMP
CS3
DIK
DU5
E3Z
EBD
EBS
EJD
EMOBN
F5P
GROUPED_DOAJ
JMI
JSF
JSH
KQ8
MOJWN
OK1
OVT
P2P
RJT
RNS
RPM
RZJ
SV3
TKC
TR2
X7M
XSB
ZGI
ZXP
AAYXX
CITATION
ACRZS
CGR
CUY
CVF
ECM
EIF
M~E
NPM
7X8
ID FETCH-LOGICAL-c498t-274e96c27d5c514d3624c6bf27908561aa8ac5f7bbc64861332271a58956c8f73
ISSN 0918-8959
1348-4540
IngestDate Fri Jul 11 13:23:45 EDT 2025
Wed Feb 19 02:35:01 EST 2025
Tue Jul 01 01:17:23 EDT 2025
Thu Apr 24 23:05:22 EDT 2025
Wed Sep 03 06:30:13 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c498t-274e96c27d5c514d3624c6bf27908561aa8ac5f7bbc64861332271a58956c8f73
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.jstage.jst.go.jp/article/endocrj/59/7/59_EJ11-0400/_article/-char/en
PMID 22481143
PQID 1030874970
PQPubID 23479
PageCount 5
ParticipantIDs proquest_miscellaneous_1030874970
pubmed_primary_22481143
crossref_primary_10_1507_endocrj_EJ11_0400
crossref_citationtrail_10_1507_endocrj_EJ11_0400
jstage_primary_article_endocrj_59_7_59_EJ11_0400_article_char_en
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2012-00-00
PublicationDateYYYYMMDD 2012-01-01
PublicationDate_xml – year: 2012
  text: 2012-00-00
PublicationDecade 2010
PublicationPlace Japan
PublicationPlace_xml – name: Japan
PublicationTitle Endocrine Journal
PublicationTitleAlternate Endocr J
PublicationYear 2012
Publisher The Japan Endocrine Society
Publisher_xml – name: The Japan Endocrine Society
References 11. Ziolkowska H, Brzewski M, Roszkowska-Blaim M (2008) Determinants of the intima-media thickness in children and adolescents with chronic kidney disease. Pediatr Nephrol 23: 805-811.
14. Ishimura E, Taniwaki H, Tabata T, et al. (2005) Cross-sectional association of serum phosphate with carotid intima-medial thickness in hemodialysis patients. Am J Kidney Dis45: 859-865.
8. Chambless LE, Heiss G, Folsom AR, et al. (1997) Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The atherosclerosis risk in community study. Am J Epidemiol 146: 483-494.
3. Giachelli CM (2004) Vascular calcification mechanisms. J Am Soc Nephrol 15: 2959-2964.
13. Lumachi F, Ermani M, Frego M, et al. (2006) Intima-media thickness measurement of the carotid artery in patients with primary hyperparathyroidism. A prospective case-control study and long term follow-up. In Vivo 20: 887-890.
4. Ketteler M, Giachelli C (2006) Novel insights into vascular calcification. Kidney Int 70: S5-S9.
7. Bhadada SK, Bhansali A, Upreti V, Subbiah S, Khandelwal N (2011) Spectrum of neurological manifestations of idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neurol India 59:586-589.
9. Bots ML, Evans GW, Ward A, Riley WA, Grobbee DE (2003) Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view. Stroke 34: 2985-2994.
5. Drueke TB, Massy ZA (2002) Advanced oxidation protein products, parathyroid hormone and vascular calcification in uremia. Blood Purif 20: 494-497.
10. Prasad N, Kumar S, Singh A, et al. (2009) Carotid intima thickness and flow-mediated dilatation in diabetic and nondiabetic continuous ambulatory peritoneal dialysis patients. Perit Dial Int 29: S96-S101.
1. Tentori F, Blayney MJ, Albert JM, et al. (2008) Mortality risk for dialysis patients with different levels of serum calcium, phosphorus and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 52: 519-530.
12. Choi HS, Kim SH, Rhee Y, Cho MA, Lee EJ, Lim SK (2008) Serum parathyroid hormone is associated with carotid intima-media thickness in postmenopausal women. Int J Clin Pract 62: 1352-1357.
2. Kestenbaum B, Sampson JN, Rudser KD, et al. (2005) Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 16: 520-528.
6. Galassi A, Spiegel DM, Bellasi A, Block GA, Raggi P (2006) Accelerated vascular calcification and relative hypoparathyroidism in incident haemodialysis diabetic patients receiving calcium binders. Nephrol Dial Transplant 21: 3215-3222.
11
12
13
1
2
3
4
5
6
7
8
9
10
References_xml – reference: 5. Drueke TB, Massy ZA (2002) Advanced oxidation protein products, parathyroid hormone and vascular calcification in uremia. Blood Purif 20: 494-497.
– reference: 11. Ziolkowska H, Brzewski M, Roszkowska-Blaim M (2008) Determinants of the intima-media thickness in children and adolescents with chronic kidney disease. Pediatr Nephrol 23: 805-811.
– reference: 8. Chambless LE, Heiss G, Folsom AR, et al. (1997) Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The atherosclerosis risk in community study. Am J Epidemiol 146: 483-494.
– reference: 4. Ketteler M, Giachelli C (2006) Novel insights into vascular calcification. Kidney Int 70: S5-S9.
– reference: 7. Bhadada SK, Bhansali A, Upreti V, Subbiah S, Khandelwal N (2011) Spectrum of neurological manifestations of idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neurol India 59:586-589.
– reference: 3. Giachelli CM (2004) Vascular calcification mechanisms. J Am Soc Nephrol 15: 2959-2964.
– reference: 2. Kestenbaum B, Sampson JN, Rudser KD, et al. (2005) Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 16: 520-528.
– reference: 10. Prasad N, Kumar S, Singh A, et al. (2009) Carotid intima thickness and flow-mediated dilatation in diabetic and nondiabetic continuous ambulatory peritoneal dialysis patients. Perit Dial Int 29: S96-S101.
– reference: 12. Choi HS, Kim SH, Rhee Y, Cho MA, Lee EJ, Lim SK (2008) Serum parathyroid hormone is associated with carotid intima-media thickness in postmenopausal women. Int J Clin Pract 62: 1352-1357.
– reference: 9. Bots ML, Evans GW, Ward A, Riley WA, Grobbee DE (2003) Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view. Stroke 34: 2985-2994.
– reference: 13. Lumachi F, Ermani M, Frego M, et al. (2006) Intima-media thickness measurement of the carotid artery in patients with primary hyperparathyroidism. A prospective case-control study and long term follow-up. In Vivo 20: 887-890.
– reference: 6. Galassi A, Spiegel DM, Bellasi A, Block GA, Raggi P (2006) Accelerated vascular calcification and relative hypoparathyroidism in incident haemodialysis diabetic patients receiving calcium binders. Nephrol Dial Transplant 21: 3215-3222.
– reference: 1. Tentori F, Blayney MJ, Albert JM, et al. (2008) Mortality risk for dialysis patients with different levels of serum calcium, phosphorus and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 52: 519-530.
– reference: 14. Ishimura E, Taniwaki H, Tabata T, et al. (2005) Cross-sectional association of serum phosphate with carotid intima-medial thickness in hemodialysis patients. Am J Kidney Dis45: 859-865.
– ident: 2
  doi: 10.1681/ASN.2004070602
– ident: 4
  doi: 10.1038/sj.ki.5001996
– ident: 9
  doi: 10.1161/01.STR.0000102044.27905.B5
– ident: 8
  doi: 10.1093/oxfordjournals.aje.a009302
– ident: 6
  doi: 10.1093/ndt/gfl395
– ident: 11
  doi: 10.1007/s00467-007-0733-6
– ident: 12
  doi: 10.1111/j.1742-1241.2008.01801.x
– ident: 10
– ident: 5
  doi: 10.1159/000065203
– ident: 1
  doi: 10.1053/j.ajkd.2008.03.020
– ident: 7
  doi: 10.4103/0028-3886.84342
– ident: 13
  doi: 10.1053/j.ajkd.2005.02.008
– ident: 3
  doi: 10.1097/01.ASN.0000145894.57533.C4
SSID ssj0033543
Score 1.9673592
Snippet Alteration in calcium and phosphate levels predisposes to increase in carotid intima media thickness (CIMT) as in chronic kidney disease. However, information...
SourceID proquest
pubmed
crossref
jstage
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 555
SubjectTerms Adolescent
Adult
Calcium - blood
Calcium - metabolism
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Cardiovascular risk
Carotid Intima-Media Thickness
Case-Control Studies
Child
Female
Humans
Hypoparathyroidism
Hypoparathyroidism - complications
Hypoparathyroidism - diagnostic imaging
Hypoparathyroidism - physiopathology
Male
Middle Aged
Parathyroid Hormone - blood
Parathyroid Hormone - metabolism
Pilot Projects
Risk Factors
Young Adult
Title Carotid intima media thickness in patients with sporadic idiopathic hypoparathyroidism: a pilot study
URI https://www.jstage.jst.go.jp/article/endocrj/59/7/59_EJ11-0400/_article/-char/en
https://www.ncbi.nlm.nih.gov/pubmed/22481143
https://www.proquest.com/docview/1030874970
Volume 59
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Endocrine Journal, 2012, Vol.59(7), pp.555-559
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKQIgXxDflS0biiSgj3455AqGhaWhISCsaT5FjuzRlS6otfSj_Bv8wd7bjFsoQQ5WsyrnYTu6X8935fCbkRcQSEfNah7UopmFWyzTkBWchzJxFXJayzhWu6B5-LPYn2cFxfjwa_diIWlr29a78_sd9Jf_DVagDvuIu2Utw1jcKFfAf-AslcBjKf-IxRmv0DWZP6ptTYXeBBBjA_s0IsHXaVLeHDU1YoRoZNKrpzFnEMpitFp3J_z1bnXVQbwMxRLBoTrp-I_vs4L1vVSdxx2CwOUIM4FkurCL6RZzPlNYLb-jPhIKfdT-3c7EKTFi3d-3MhPHsfG4wVYBfGJpgIGRjL5y6XpxzIt70VPK4DEvu0n1rK11T9F7mNj_TIH4dhYUZ25Cluc3f66bl3NJtSfzcBHlo8_Dz3b0D9PhmUbSe3oYl_d9mPR-LiFYQNFK5JipsosImrpCrCWMxisoPn_zSVJrmNhRzeD63VA5NvNoaxS_KzrU56Ptf9cWmjFFpjm6Rm84WoW8tsG6TkW7vkOuHLtriLtEOX9Tiixp8UY8vqKYDvijiiw74omt80W18vaaCGnRRg657ZPJ-7-jdfuiO5Qhlxss-TFimeSETpnIJ6rYCFSiTRT1NGAf9vYiFKIXMp6yuZZGVoC7CnMFikcPLKmQ5Zel9stN2rX5IKFj7ElQksHnTLKsVF4mKgCACpViVXKsxiYb3V0mXsx6PTjmpLuTamLz0tyxswpa_Eb-xTPGk7lv2pDmvGBb-Fk-BuyKBbEyeD-ysQDLjcptodbc8r2KTbTPjDLp5YPnsuwHFuYzBVHl0mdE-JjfwG7MOwCdkpz9b6qegEvf1MwPRn-uRvI8
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Carotid+intima+media+thickness+in+patients+with+sporadic+idiopathic+hypoparathyroidism%3A+a+pilot+study&rft.jtitle=Endocrine+journal&rft.au=Gupta%2C+Yashdeep&rft.au=Bhadada%2C+Sanjay+Kumar&rft.au=Shah%2C+Viral+N&rft.au=Upreti%2C+Vimal&rft.date=2012&rft.issn=0918-8959&rft.eissn=1348-4540&rft.volume=59&rft.issue=7&rft.spage=555&rft.epage=559&rft_id=info:doi/10.1507%2Fendocrj.EJ11-0400&rft.externalDBID=n%2Fa&rft.externalDocID=10_1507_endocrj_EJ11_0400
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0918-8959&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0918-8959&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0918-8959&client=summon