Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

• Published in: International Journal of Obesity Vol. 44; no. 9; pp. 1946 - 1957
• Main Authors: Wargent, Edward T, Martin-Gronert, Malgorzata S, Cripps, Roselle L, Heisler, Lora K, Yeo, Giles S H, Ozanne, Susan E, Arch, Jonathan R S, Stocker, Claire J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.09.2020
• Subjects: Agonists; Animals; Appetite; Appetite - physiology; Appetite loss; Arcuate nucleus; Body weight; Body Weight - physiology; Brain; Cannulation; Diet; Feeding behavior; Female; Fenfluramine; Food; Food consumption; Food intake; Gene Expression Regulation, Developmental - genetics; Genes; Growth; Growth rate; Hybridization; Hyperphagia; Hypothalamus; Hypothalamus - metabolism; Lactation; Low protein diet; Male; Neonates; Neuropeptide Y; Nutrient deficiency; Nutrition; Nutritional status; Obesity - metabolism; Offspring; Phenols; Polymerase chain reaction; Proteins; Rats; Receptors; Receptors, Serotonin - genetics; Receptors, Serotonin - metabolism; Sensitivity; Serotonin; Serotonin S5 receptors; Statistics; Transcriptome - genetics; Ventricle; Ventricles (cerebral)

Though it is well established that neonatal nutrition plays a major role in lifelong offspring health, the mechanisms underpinning this have not been well defined. Early postnatal accelerated growth resulting from maternal nutritional status is associated with increased appetite and body weight. Lik...