New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity

• Published in: Acta pharmaceutica Sinica. B Vol. 11; no. 6; pp. 1648 - 1666
• Main Authors: Su, Lihua, Zhang, Xintian, Ma, Yunbao, Geng, Changan, Huang, Xiaoyan, Hu, Jing, Li, Tianze, Tang, Shuang, Shen, Cheng, Gao, Zhen, Zhang, Xuemei, Chen, Ji-Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2021; Elsevier
• Subjects: Apoptosis; Artematrolides A–R; Artemisia atrovirens; Cell cycle; Cytotoxicity; Guaianolide dimers; Original; Guaianolide dimers; Cytotoxicity; Artemisia atrovirens; Artematrolides A–R; Cell cycle; Apoptosis

Leading by cytotoxicity against HepG2 cells, bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers, artematrolides A–R and lavandiolides A, B, C, H, and J. Eight compounds (1, 4, 10, 12, 13, and 19–21) were unambiguously co...