Human Cytomegalovirus Latency-Associated Proteins Elicit Immune-Suppressive IL-10 Producing CD4+ T Cells

• Published in: PLoS pathogens Vol. 9; no. 10; p. e1003635
• Main Authors: Mason, Gavin M., Jackson, Sarah, Okecha, Georgina, Poole, Emma, Sissons, J. G. Patrick, Sinclair, John, Wills, Mark R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2013; Public Library of Science (PLoS)
• Subjects: CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; Cytomegalovirus - physiology; Cytomegalovirus Infections - genetics; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - pathology; Female; Humans; Immune system; Immunology; Infections; Interferon-gamma - genetics; Interferon-gamma - immunology; Interleukin-10 - genetics; Interleukin-10 - immunology; Male; Microbiology; Receptors, Chemokine - genetics; Receptors, Chemokine - immunology; T cell receptors; Viral Proteins - genetics; Viral Proteins - immunology; Virus Latency - physiology

Human cytomegalovirus (HCMV) is a widely prevalent human herpesvirus, which, after primary infection, persists in the host for life. In healthy individuals, the virus is well controlled by the HCMV-specific T cell response. A key feature of this persistence, in the face of a normally robust host imm...