Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit

The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed. All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of medicine Vol. 128; no. 7; pp. 785 - 789
Main Authors Soo Hoo, Guy W., Lin, Henry K., Junaid, Imran, Klaustermeyer, William B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2015
Elsevier Sequoia S.A
Subjects
ACE inhibitors
Age Distribution
Aged
Angioedema
Angioedema - chemically induced
Angioedema - mortality
Angioedema - therapy
Angiotensin-converting enzyme inhibitor
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Clinical outcomes
Cohort Studies
Confidence Intervals
Critical Care - methods
Critical Care - statistics & numerical data
Enzymes
Follow-Up Studies
Hospital Mortality
Humans
Incidence
Intensive care
Intensive Care Units - utilization
Internal Medicine
Logistic Models
Male
Middle Aged
Odds Ratio
Patient Admission - statistics & numerical data
Respiration, Artificial - methods
Respiratory diseases
Respiratory failure
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Rate
Tracheostomy - methods
Respiratory failure
Angiotensin-converting enzyme inhibitor
Angioedema
Online AccessGet full text
ISSN0002-9343
1555-7162
1555-7162
DOI10.1016/j.amjmed.2015.02.006

Cover

Abstract The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed. All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support. Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
AbstractList The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed. All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support. Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed. All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support. Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
Abstract Objective The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Methods Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed. Results All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support ( P < .01). Hypercapnia (PaCO2  = 45.2 ± 6.7; P  = 0.046) also identified patients needing ventilatory support. Conclusions Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit.OBJECTIVEThe purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit.Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed.METHODSFifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed.All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support.RESULTSAll 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support.Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.CONCLUSIONSVentilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
Here, Soo Hoo et al review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support. entilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
Author Lin, Henry K.
Junaid, Imran
Klaustermeyer, William B.
Soo Hoo, Guy W.
Author_xml – sequence: 1
  givenname: Guy W.
  surname: Soo Hoo
  fullname: Soo Hoo, Guy W.
  email: guy.soohoo@va.gov
  organization: Pulmonary and Critical Care Section, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles
– sequence: 2
  givenname: Henry K.
  surname: Lin
  fullname: Lin, Henry K.
  organization: Allergy and Immunology Section, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles
– sequence: 3
  givenname: Imran
  surname: Junaid
  fullname: Junaid, Imran
  organization: Allergy and Immunology Section, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles
– sequence: 4
  givenname: William B.
  surname: Klaustermeyer
  fullname: Klaustermeyer, William B.
  organization: Allergy and Immunology Section, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25770035$$D View this record in MEDLINE/PubMed
BookMark eNqVkl9rFDEUxYNU7Lb6DUQGfPFlxpvMZP6IFJal1UJBUAu-xUzmTs04k7RJZmH99M10W4SCFJ-SwO-cXM65R-TAWIOEvKaQUaDl-yGT0zBhlzGgPAOWAZTPyIpyztOKluyArACApU1e5IfkyPshPqHh5QtyyHhVAeR8RX6uzZW2AY3XJlXWbNEFba6SU_NnN2Fybn7pVgfrkjsOO5xk8hVvZu0Wat1N2nttTRJsIk3E75y2mGykw-TS6PCSPO_l6PHV_XlMLs9Ov28-pxdfPp1v1hepKpo6pKwASvuS5jnlquS84BW2fS9pDwpYX1Xxmrd9xzn0dVuwhuesk0VR9TUtmqLJj8m7ve-1szcz-iDiaArHURq0sxe0bIBBXeVlRN8-Qgc7OxOnW6gSgOdQR-rNPTW3MWZx7fQk3U48ZBeBD3tAOeu9w14oHWSIaQQn9SgoiKUoMYh9UWIpSgATsagoLh6JH_yfkJ3sZRij3Gp0wiuNRmGnHaogOqv_10CN2mglx9-4Q_83COGjQHxbVmjZIMoBaFX-iAYf_23w9P-3InnWcQ
CODEN AJMEAZ
CitedBy_id crossref_primary_10_30895_2312_7821_2023_11_2_231_240
crossref_primary_10_1007_s40521_016_0099_8
crossref_primary_10_1515_dmpt_2023_0008
crossref_primary_10_1111_bcp_13090
crossref_primary_10_2217_pgs_2017_0063
Cites_doi 10.1016/j.otohns.2008.03.029
10.1016/j.otohns.2007.08.012
10.2500/aap.2013.34.3618
10.1288/00005537-199203000-00005
10.1136/bmj.38803.528113.55
10.1016/S0140-6736(97)09137-X
10.1016/S1081-1206(10)60208-6
10.1001/2013.jamainternmed.34
10.1001/archotol.130.12.1416
10.1177/000348941011901208
10.1161/HYPERTENSIONAHA.108.110270
10.1520/JFS15129J
10.1001/archinte.165.14.1637
10.1016/S1081-1206(10)60594-7
10.1046/j.1365-2125.1999.00093.x
10.1378/chest.126.2.400
10.1016/S1081-1206(10)60267-0
10.1086/496899
ContentType Journal Article
Copyright 2015
Published by Elsevier Inc.
Copyright Elsevier Science Ltd. Jul 2015
Copyright_xml – notice: 2015
– notice: Published by Elsevier Inc.
– notice: Copyright Elsevier Science Ltd. Jul 2015
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7TK
7TO
7TS
7U9
H94
K9.
7X8
DOI 10.1016/j.amjmed.2015.02.006
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
Neurosciences Abstracts
Oncogenes and Growth Factors Abstracts
Physical Education Index
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Oncogenes and Growth Factors Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Immunology Abstracts
Neurosciences Abstracts
Physical Education Index
MEDLINE - Academic
DatabaseTitleList MEDLINE


MEDLINE - Academic
Virology and AIDS Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1555-7162
EndPage 789
ExternalDocumentID 3742354391
25770035
10_1016_j_amjmed_2015_02_006
S000293431500176X
1_s2_0_S000293431500176X
Genre Journal Article
GroupedDBID ---
--K
-~X
.-4
.1-
.55
.FO
.GJ
0R~
123
1B1
1CY
1P~
1RT
1~5
23M
3O-
4.4
457
4CK
4G.
53G
5RE
5VS
6J9
7-5
AAEDT
AAEDW
AAFWJ
AALRI
AAQFI
AAQQT
AAQXK
AAWTL
AAXUO
AAYWO
ABLJU
ABMAC
ABOCM
ABPPZ
ABWVN
ACGFO
ACIUM
ACKOT
ACPRK
ACRPL
ACVFH
ADBBV
ADCNI
ADMUD
ADNMO
ADVLN
AENEX
AEUPX
AEVXI
AFFNX
AFHKK
AFJKZ
AFPUW
AFRHN
AFTJW
AGCQF
AGHFR
AGQPQ
AHHHB
AHMBA
AIGII
AITUG
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
APXCP
ASPBG
AVWKF
AZFZN
BELOY
BKOMP
C5W
CS3
EBS
EFJIC
EFKBS
EJD
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
G-2
G-Q
GBLVA
HEA
HMK
HMO
HVGLF
HZ~
IH2
IHE
J1W
J5H
K-O
KOM
L7B
LZ2
M29
M41
MO0
MVM
N4W
N9A
NQ-
O9-
OD.
OHT
OO~
P2P
PC.
PQQKQ
R2-
ROL
RPZ
SAE
SEL
SES
SSZ
TWZ
UBY
UHB
UHU
UNMZH
UV1
WH7
WOW
WUQ
X7M
XH2
XPP
YFH
YOC
YQJ
YYQ
Z5R
ZGI
ZUP
ZXP
AACTN
AAYOK
ADPAM
AFCTW
NCXOZ
PKN
RIG
AAIAV
AGZHU
AHPSJ
ALXNB
ZA5
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7TK
7TO
7TS
7U9
H94
K9.
7X8
ID FETCH-LOGICAL-c498t-24011f613315c655457ebffa1f0c02f77fa13bfd550f8b429532da447f8149493
ISSN 0002-9343
1555-7162
IngestDate Fri Sep 05 08:10:19 EDT 2025
Sat Jul 26 02:34:33 EDT 2025
Mon Jul 21 05:55:29 EDT 2025
Tue Jul 01 00:44:33 EDT 2025
Thu Apr 24 22:53:10 EDT 2025
Fri Feb 23 02:17:01 EST 2024
Sun Feb 23 10:18:48 EST 2025
Tue Aug 26 16:58:40 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords Respiratory failure
Angiotensin-converting enzyme inhibitor
Angioedema
Language English
License Published by Elsevier Inc.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c498t-24011f613315c655457ebffa1f0c02f77fa13bfd550f8b429532da447f8149493
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMID 25770035
PQID 1696005308
PQPubID 950
PageCount 5
ParticipantIDs proquest_miscellaneous_1690208736
proquest_journals_1696005308
pubmed_primary_25770035
crossref_citationtrail_10_1016_j_amjmed_2015_02_006
crossref_primary_10_1016_j_amjmed_2015_02_006
elsevier_sciencedirect_doi_10_1016_j_amjmed_2015_02_006
elsevier_clinicalkeyesjournals_1_s2_0_S000293431500176X
elsevier_clinicalkey_doi_10_1016_j_amjmed_2015_02_006
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2015-07-01
PublicationDateYYYYMMDD 2015-07-01
PublicationDate_xml – month: 07
  year: 2015
  text: 2015-07-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle The American journal of medicine
PublicationTitleAlternate Am J Med
PublicationYear 2015
Publisher Elsevier Inc
Elsevier Sequoia S.A
Publisher_xml – name: Elsevier Inc
– name: Elsevier Sequoia S.A
References Bluestein, Hoover, Banerji (bib6) 2009; 103
Dean, Schultz, Powers (bib17) 2001; 46
Nussberger, Cugno, Amstutz (bib11) 1998; 351
Lin, Shah (bib1) 2008; 101
IMS Institute for Healthcare Informatics (bib16) 2011
Tai, Mascaro, Goldstein (bib14) 2010; 119
Grant, Deeb, Chia (bib18) 2007; 137
McDowell, Coleman, Ferner (bib9) 2006; 332
Banerji, Clark, Blanda (bib5) 2008; 100
Sondhi, Lippmann, Murali (bib13) 2004; 126
Mahoney, Devaiah (bib8) 2008; 139
Lin, Levine, Lin (bib2) 2013; 34
Gibbs, Lip, Beevers (bib7) 1999; 48
Duan, Nikpoor, Dube (bib19) 2005; 77
Miller, Oliveria, Berlowitz (bib4) 2008; 51
Megerian, Arnold, Berger (bib15) 1992; 102
Kyrmizakis, Papadakis, Liolios (bib12) 2004; 130
Toh, Reichman, Houstoun (bib3) 2012; 172
Kostis, Kim, Rusnak (bib10) 2005; 165
Gibbs (10.1016/j.amjmed.2015.02.006_bib7) 1999; 48
Lin (10.1016/j.amjmed.2015.02.006_bib2) 2013; 34
Sondhi (10.1016/j.amjmed.2015.02.006_bib13) 2004; 126
IMS Institute for Healthcare Informatics (10.1016/j.amjmed.2015.02.006_bib16) 2011
Duan (10.1016/j.amjmed.2015.02.006_bib19) 2005; 77
Toh (10.1016/j.amjmed.2015.02.006_bib3) 2012; 172
Mahoney (10.1016/j.amjmed.2015.02.006_bib8) 2008; 139
Nussberger (10.1016/j.amjmed.2015.02.006_bib11) 1998; 351
Miller (10.1016/j.amjmed.2015.02.006_bib4) 2008; 51
Kyrmizakis (10.1016/j.amjmed.2015.02.006_bib12) 2004; 130
Bluestein (10.1016/j.amjmed.2015.02.006_bib6) 2009; 103
Kostis (10.1016/j.amjmed.2015.02.006_bib10) 2005; 165
Dean (10.1016/j.amjmed.2015.02.006_bib17) 2001; 46
Grant (10.1016/j.amjmed.2015.02.006_bib18) 2007; 137
Megerian (10.1016/j.amjmed.2015.02.006_bib15) 1992; 102
Lin (10.1016/j.amjmed.2015.02.006_bib1) 2008; 101
Banerji (10.1016/j.amjmed.2015.02.006_bib5) 2008; 100
McDowell (10.1016/j.amjmed.2015.02.006_bib9) 2006; 332
Tai (10.1016/j.amjmed.2015.02.006_bib14) 2010; 119
References_xml – volume: 46
  start-page: 1239
  year: 2001
  end-page: 1243
  ident: bib17
  article-title: Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease
  publication-title: J Forensic Sci
– volume: 332
  start-page: 1177
  year: 2006
  end-page: 1181
  ident: bib9
  article-title: Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine
  publication-title: BMJ
– volume: 130
  start-page: 1416
  year: 2004
  end-page: 1419
  ident: bib12
  article-title: Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists
  publication-title: Arch Otolaryngol Head Neck Surg
– year: 2011
  ident: bib16
  article-title: The Use of Medicines in the US: Review of 2010
– volume: 137
  start-page: 931
  year: 2007
  end-page: 935
  ident: bib18
  article-title: Clinical experience with angiotensin-converting enzyme inhibitor-induced angioedema
  publication-title: Otolaryngol Head Neck Surg
– volume: 351
  start-page: 1693
  year: 1998
  end-page: 1697
  ident: bib11
  article-title: Plasma bradykinin in angio-oedema
  publication-title: Lancet
– volume: 100
  start-page: 327
  year: 2008
  end-page: 332
  ident: bib5
  article-title: Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department
  publication-title: Ann Allergy Asthma Immunol
– volume: 48
  start-page: 861
  year: 1999
  end-page: 865
  ident: bib7
  article-title: Angioedema due to ACE inhibitors: increased risk in patients of African origin
  publication-title: Br J Clin Pharmacol
– volume: 101
  start-page: 185
  year: 2008
  end-page: 192
  ident: bib1
  article-title: Increasing hospitalizations due to angioedema in the United States
  publication-title: Ann Allergy Asthma Immunol
– volume: 172
  start-page: 1582
  year: 2012
  end-page: 1589
  ident: bib3
  article-title: Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system
  publication-title: Arch Intern Med
– volume: 139
  start-page: 105
  year: 2008
  end-page: 108
  ident: bib8
  article-title: Angioedema and angiotensin-converting enzyme inhibitors: are demographics a risk?
  publication-title: Otolaryngol Head Neck Surg
– volume: 34
  start-page: 65
  year: 2013
  end-page: 71
  ident: bib2
  article-title: Adverse drug effects and angioedema hospitalizations in the United States from 2000 to 2009
  publication-title: Allergy Asthma Proc
– volume: 103
  start-page: 502
  year: 2009
  end-page: 507
  ident: bib6
  article-title: Angiotensin-converting enzyme inhibitor-induced angioedema in a community hospital emergency department
  publication-title: Ann Allergy Asthma Immunol
– volume: 165
  start-page: 1637
  year: 2005
  end-page: 1642
  ident: bib10
  article-title: Incidence and characteristics of angioedema associated with enalapril
  publication-title: Arch Intern Med
– volume: 126
  start-page: 400
  year: 2004
  end-page: 404
  ident: bib13
  article-title: Airway compromise due to angiotensin-converting enzyme inhibitor-induced angioedema: clinical experience at a large community teaching hospital
  publication-title: Chest
– volume: 119
  start-page: 836
  year: 2010
  end-page: 841
  ident: bib14
  article-title: Angioedema: a review of 367 episodes presenting to three tertiary care hospitals
  publication-title: Ann Otol Rhinol Laryngol
– volume: 51
  start-page: 1624
  year: 2008
  end-page: 1630
  ident: bib4
  article-title: Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors
  publication-title: Hypertension
– volume: 102
  start-page: 256
  year: 1992
  end-page: 260
  ident: bib15
  article-title: Angioedema: 5 years' experience, with a review of the disorder's presentation and treatment
  publication-title: Laryngoscope
– volume: 77
  start-page: 617
  year: 2005
  end-page: 626
  ident: bib19
  article-title: A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors
  publication-title: Am J Hum Genet
– volume: 139
  start-page: 105
  issue: 1
  year: 2008
  ident: 10.1016/j.amjmed.2015.02.006_bib8
  article-title: Angioedema and angiotensin-converting enzyme inhibitors: are demographics a risk?
  publication-title: Otolaryngol Head Neck Surg
  doi: 10.1016/j.otohns.2008.03.029
– volume: 137
  start-page: 931
  issue: 6
  year: 2007
  ident: 10.1016/j.amjmed.2015.02.006_bib18
  article-title: Clinical experience with angiotensin-converting enzyme inhibitor-induced angioedema
  publication-title: Otolaryngol Head Neck Surg
  doi: 10.1016/j.otohns.2007.08.012
– volume: 34
  start-page: 65
  issue: 1
  year: 2013
  ident: 10.1016/j.amjmed.2015.02.006_bib2
  article-title: Adverse drug effects and angioedema hospitalizations in the United States from 2000 to 2009
  publication-title: Allergy Asthma Proc
  doi: 10.2500/aap.2013.34.3618
– volume: 102
  start-page: 256
  issue: 3
  year: 1992
  ident: 10.1016/j.amjmed.2015.02.006_bib15
  article-title: Angioedema: 5 years' experience, with a review of the disorder's presentation and treatment
  publication-title: Laryngoscope
  doi: 10.1288/00005537-199203000-00005
– volume: 332
  start-page: 1177
  issue: 7551
  year: 2006
  ident: 10.1016/j.amjmed.2015.02.006_bib9
  article-title: Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine
  publication-title: BMJ
  doi: 10.1136/bmj.38803.528113.55
– volume: 351
  start-page: 1693
  issue: 9117
  year: 1998
  ident: 10.1016/j.amjmed.2015.02.006_bib11
  article-title: Plasma bradykinin in angio-oedema
  publication-title: Lancet
  doi: 10.1016/S0140-6736(97)09137-X
– volume: 101
  start-page: 185
  issue: 2
  year: 2008
  ident: 10.1016/j.amjmed.2015.02.006_bib1
  article-title: Increasing hospitalizations due to angioedema in the United States
  publication-title: Ann Allergy Asthma Immunol
  doi: 10.1016/S1081-1206(10)60208-6
– volume: 172
  start-page: 1582
  issue: 20
  year: 2012
  ident: 10.1016/j.amjmed.2015.02.006_bib3
  article-title: Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system
  publication-title: Arch Intern Med
  doi: 10.1001/2013.jamainternmed.34
– year: 2011
  ident: 10.1016/j.amjmed.2015.02.006_bib16
– volume: 130
  start-page: 1416
  issue: 12
  year: 2004
  ident: 10.1016/j.amjmed.2015.02.006_bib12
  article-title: Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists
  publication-title: Arch Otolaryngol Head Neck Surg
  doi: 10.1001/archotol.130.12.1416
– volume: 119
  start-page: 836
  issue: 12
  year: 2010
  ident: 10.1016/j.amjmed.2015.02.006_bib14
  article-title: Angioedema: a review of 367 episodes presenting to three tertiary care hospitals
  publication-title: Ann Otol Rhinol Laryngol
  doi: 10.1177/000348941011901208
– volume: 51
  start-page: 1624
  issue: 6
  year: 2008
  ident: 10.1016/j.amjmed.2015.02.006_bib4
  article-title: Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.110270
– volume: 46
  start-page: 1239
  issue: 5
  year: 2001
  ident: 10.1016/j.amjmed.2015.02.006_bib17
  article-title: Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease
  publication-title: J Forensic Sci
  doi: 10.1520/JFS15129J
– volume: 165
  start-page: 1637
  issue: 14
  year: 2005
  ident: 10.1016/j.amjmed.2015.02.006_bib10
  article-title: Incidence and characteristics of angioedema associated with enalapril
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.165.14.1637
– volume: 100
  start-page: 327
  issue: 4
  year: 2008
  ident: 10.1016/j.amjmed.2015.02.006_bib5
  article-title: Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department
  publication-title: Ann Allergy Asthma Immunol
  doi: 10.1016/S1081-1206(10)60594-7
– volume: 48
  start-page: 861
  issue: 6
  year: 1999
  ident: 10.1016/j.amjmed.2015.02.006_bib7
  article-title: Angioedema due to ACE inhibitors: increased risk in patients of African origin
  publication-title: Br J Clin Pharmacol
  doi: 10.1046/j.1365-2125.1999.00093.x
– volume: 126
  start-page: 400
  issue: 2
  year: 2004
  ident: 10.1016/j.amjmed.2015.02.006_bib13
  article-title: Airway compromise due to angiotensin-converting enzyme inhibitor-induced angioedema: clinical experience at a large community teaching hospital
  publication-title: Chest
  doi: 10.1378/chest.126.2.400
– volume: 103
  start-page: 502
  issue: 6
  year: 2009
  ident: 10.1016/j.amjmed.2015.02.006_bib6
  article-title: Angiotensin-converting enzyme inhibitor-induced angioedema in a community hospital emergency department
  publication-title: Ann Allergy Asthma Immunol
  doi: 10.1016/S1081-1206(10)60267-0
– volume: 77
  start-page: 617
  issue: 4
  year: 2005
  ident: 10.1016/j.amjmed.2015.02.006_bib19
  article-title: A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors
  publication-title: Am J Hum Genet
  doi: 10.1086/496899
SSID ssj0000956
Score 2.1950226
Snippet The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. Fifty...
Abstract Objective The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an...
Here, Soo Hoo et al review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. All 50 subjects...
The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 785
SubjectTerms ACE inhibitors
Age Distribution
Aged
Angioedema
Angioedema - chemically induced
Angioedema - mortality
Angioedema - therapy
Angiotensin-converting enzyme inhibitor
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Clinical outcomes
Cohort Studies
Confidence Intervals
Critical Care - methods
Critical Care - statistics & numerical data
Enzymes
Follow-Up Studies
Hospital Mortality
Humans
Incidence
Intensive care
Intensive Care Units - utilization
Internal Medicine
Logistic Models
Male
Middle Aged
Odds Ratio
Patient Admission - statistics & numerical data
Respiration, Artificial - methods
Respiratory diseases
Respiratory failure
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Rate
Tracheostomy - methods
Title Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit
URI https://www.clinicalkey.com/#!/content/1-s2.0-S000293431500176X
https://www.clinicalkey.es/playcontent/1-s2.0-S000293431500176X
https://dx.doi.org/10.1016/j.amjmed.2015.02.006
https://www.ncbi.nlm.nih.gov/pubmed/25770035
https://www.proquest.com/docview/1696005308
https://www.proquest.com/docview/1690208736
Volume 128
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKJiFeEPcVBjISb1Wm3J08llEolCLENm1vxrkYWq0J6uWh-4f8K86xEydaW23sJYpiO5dzvvgcH58LIe_cNPBiJ4ot0O1Dyxd2ZIksh8WKTGInkCimMTh5_C0cnvlfLoKLTudvy2tptUyO0qutcSV34SpcA75ilOx_cNbcFC7AOfAXjsBhON6Kx_3i16RULuiFpdzH58qJeVBcrWfoE_l7ksAPO--pfnmWzwSQE11_lS0kAxajrQzVT6Ftg9qZHWOSlDLa1lxPmxCUop1v4vrm_ElZ9oalMsB-Wq1752r2GX9Qx-9mX-qrTl2gQiR6o6qP8eZZFWKikPd5NtcG2qZxdImZikCe5GuNtspi1Hvfvktlx3AC4_PanptjTydtMnOzG7VAyFozLdOVfiqhzXQdog15oE0T0yMxmwI50JMv0Clat6TfHhyPHGsBjdYJvgu-CmjLMGOpUovX03I7fOFym290vUf2XcbQY2C_P_pxPmrUgliVEjafWcdxKmfDzffbpSftWgcpfej0EXlYLWRoX6PyMenkxRNyf1yh4Sn5uR2cVIOTGnDSBpzUgJMacNJlSUVBDTgpgpMiOJ-Rs4-D0-OhVZXzsFI_jpa4j-c4EtRHoFUaghobsDyRUjjSTm1XMganXiIzWDPLKAE9KfDcTPg-k5GDOZS852SvKIv8gFAZ5SCnRMyEyHwWpgnIpSwBCSLchCWZ2yVeTTyeVrnuseTKJa-dGqdck5wjybkNrLTDLrHMqD8618sN_YOaL7yOYwbJywF8N4xj28bli-rnXfBd4GqPrDRkrfne4pmHNXB485gwDlEK21GXvDXNwF_cNBRFXq5UH6zjyzy4xQsNOEMcEPcMXRFe3vmDXpEHzVxwSPaW81X-GrT8ZfKm-n_-Adrs9sU
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Angiotensin-converting+Enzyme+Inhibitor+Angioedema+Requiring+Admission+to+an+Intensive+Care+Unit&rft.jtitle=The+American+journal+of+medicine&rft.au=Soo+Hoo%2C+Guy+W.%2C+MD%2C+MPH&rft.au=Lin%2C+Henry+K.%2C+MD&rft.au=Junaid%2C+Imran%2C+MD&rft.au=Klaustermeyer%2C+William+B.%2C+MD&rft.date=2015-07-01&rft.issn=0002-9343&rft.volume=128&rft.issue=7&rft.spage=785&rft.epage=789&rft_id=info:doi/10.1016%2Fj.amjmed.2015.02.006&rft.externalDBID=ECK1-s2.0-S000293431500176X&rft.externalDocID=1_s2_0_S000293431500176X
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00029343%2FS0002934314X00094%2Fcov150h.gif