Micronuclei in the peripheral blood and bone marrow cells of rats exposed to 2450 MHz radiofrequency radiation

• Published in: International journal of radiation biology Vol. 77; no. 11; pp. 1109 - 1115
• Main Authors: Pickard, W. F., Bisht, K. S., Prihoda, T. J., Meltz, M. L., LaRegina, M. C., Roti, J. L. Roti, Straube, W. L., Moros, E. G.
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 2001; Taylor & Francis
• Subjects: Animals; Biological and medical sciences; Biological effects of radiation; Blood Cells - physiology; Blood Cells - radiation effects; Bone Marrow Cells - physiology; Bone Marrow Cells - radiation effects; Erythrocytes - physiology; Erythrocytes - radiation effects; Fundamental and applied biological sciences. Psychology; Ionizing radiations; Male; Micronucleus Tests; Radio Waves; Rats; Rats, Sprague-Dawley; Space life sciences; Tissues, organs and organisms biophysics; Evaluation; Animal model; Micronucleus test; Rat; Rodentia; Experimental study; Blood; Dose activity relation; Vertebrata; Ionizing irradiation; Mammalia; Radiobiology; Animal; Radiofrequency irradiation; Bone marrow; Whole body; Biological effect
• ISSN: 0955-3002; 1362-3095
• DOI: 10.1080/09553000110069100

Purpose : To determine the incidence of micronuclei in peripheral blood and bone marrow cells of rats exposed continuously for 24h to 2450 MHz continuous wave radiofrequency radiation (RFR) at an average whole-body specific absorption rate (SAR) of 12W/kg. Materials and methods : Eight adult male Sprague-Dawley rats were exposed to 2450 MHz RFR in circularly polarized waveguides. Eight sham-exposed rats were kept in similar waveguides without the transmission of RFR. Four rats were treated with mitomycin-C (MMC) and used as positive controls. All rats were necropsied 24h after the end of RFR and sham exposures, and after the 24h treatment with MMC. Peripheral blood and bone marrow smears were examined to determine the frequency of micronuclei (MN) in polychromatic erythrocytes (PCE). Results : The results indicated that the incidence of MN/2000 PCE were not significantly different between RFR- and sham-exposed rats. The group mean frequencies of MN in the peripheral blood were 2.3 ±0.7 in RFR-exposed rats and 2.1 ±0.6 in sham-exposed rats. In bone marrow cells, the average MN incidence was 3.8 ±1.0 in RFR-exposed rats and 3.4 ±0.7 in sham-exposed rats. The corresponding values in positive control rats treated with MMC were 23.5 ±4.7 in the peripheral blood and 33.8 ±7.4 in bone marrow cells. Conclusion : There was no evidence for the induction of MN in peripheral blood and bone marrow cells of rats exposed for 24h to 2450 MHz continuous wave RFR at a whole body average SAR of 12 W/kg.