Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

• Published in: NPJ biofilms and microbiomes Vol. 6; no. 1; p. 16
• Main Authors: Gilijamse, Pim W., Hartstra, Annick V., Levin, Evgeni, Wortelboer, Koen, Serlie, Mireille J., Ackermans, Mariette T., Herrema, Hilde, Nederveen, Aart J., Imangaliyev, Sultan, Aalvink, Steven, Sommer, Morton, Levels, Han, Stroes, Erik S. G., Groen, Albert K., Kemper, Marleen, de Vos, Willem M., Nieuwdorp, Max, Prodan, Andrei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.03.2020; Nature Publishing Group
• Subjects: 631/326/2565/2134; 631/326/2565/2142; 631/326/2565/855; 692/698/2741/2135; Administration, Oral; Adult; Aged; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bile Acids and Salts - metabolism; Biomedical and Life Sciences; Clostridiales - physiology; Dietary Supplements - adverse effects; Dose-Response Relationship, Drug; Dysbacteriosis; Feces - microbiology; Gastrointestinal Microbiome; Glucose; Glucose - metabolism; Humans; Insulin; Insulin resistance; Intestinal microflora; Intestine; Life Sciences; Long-term effects; Male; Medical Microbiology; Metabolic response; Metabolic syndrome; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Microbiota; Middle Aged; Pilot Projects; Sequence Analysis, DNA; Treatment Outcome
• ISSN: 2055-5008; 2055-5008
• DOI: 10.1038/s41522-020-0127-0

Dysbiosis of the intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We performed a phase I/II dose-finding and safety study on the effect of oral intake of the anaerobic butyrogenic strain Anaerobutyricum soehngenii on glucose...