Immunologic Adverse Reaction Associated with Low-carbide Metal-on-metal Bearings in Total Hip Arthroplasty

• Published in: Clinical orthopaedics and related research Vol. 468; no. 8; pp. 2135 - 2142
• Main Authors: Aroukatos, Panagiotis, Repanti, Maria, Repantis, Thomas, Bravou, Vassiliki, Korovessis, Panagiotis
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.08.2010; Springer; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip - adverse effects; Biological and medical sciences; Chromium Alloys - adverse effects; Clinical Research; Conservative Orthopedics; Diseases of the osteoarticular system; Female; Giant Cells, Foreign-Body - drug effects; Giant Cells, Foreign-Body - pathology; Hip - pathology; Hip Prosthesis - adverse effects; Humans; Hypersensitivity, Delayed - chemically induced; Hypersensitivity, Delayed - immunology; Hypersensitivity, Delayed - pathology; Male; Medical sciences; Medicine; Medicine & Public Health; Metals - adverse effects; Metals - blood; Metals - immunology; Middle Aged; Neutrophils - drug effects; Neutrophils - pathology; Orthopedic surgery; Orthopedics; Osteolysis - chemically induced; Osteolysis - immunology; Prosthesis Design; Prosthesis Failure; Reoperation; Retrospective Studies; Sports Medicine; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Orthopedics; Biologic Fixation; Periprosthetic Tissue; UHMWPE; CoCr Alloy; Wear Rate; Hip prosthesis; Orthopedic surgery; Treatment; Metal; Toxicity; Orthopedics

Background An increased incidence of periprosthetic osteolysis, resulting in loss of biologic fixation, has been reported in contemporary THAs with low-carbide metal-on-metal compared with metal-on-polyethylene couple bearings. Although a hypersensitivity reaction attributable to Co and Cr debris is...