Plant-derived soybean peroxidase stimulates osteoblast collagen biosynthesis, matrix mineralization, and accelerates bone regeneration in a sheep model

• Published in: Bone Reports Vol. 14; p. 101096
• Main Authors: Barker, Alexandra J., Arthur, Agnes, DeNichilo, Mark O., Panagopoulos, Romana, Gronthos, Stan, Anderson, Peter J., Zannettino, Andrew C.W., Evdokiou, Andreas, Panagopoulos, Vasilios
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2021; Elsevier
• Subjects: Bone repair; Collagen biosynthesis; Matrix mineralization; Osteoblast; Osteoinductive agent; Soybean peroxidase; Osteoblast; Soybean peroxidase; Collagen biosynthesis; Matrix mineralization; Bone repair; Osteoinductive agent

Bone defects arising from fractures or disease represent a significant problem for surgeons to manage and are a substantial economic burden on the healthcare economy. Recent advances in the development of biomaterial substitutes provides an attractive alternative to the current “gold standard” autol...