Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion - Su, Shao-Hua; Wu, Yi-Fang; Wang, Da-Peng; Hai, Jian (Cell death & disease, 2018)
Keywords: 101/28; 13/95; 82/1; Adenylate Kinase - metabolism; Animals; Antibodies; Autophagosomes - drug effects; Autophagosomes - metabolism; Autophagosomes - ultrastructure; Autophagy; Autophagy - drug effects; Bcl-2 protein; Beclin-1 - metabolism; Benzamides - pharmacology; Biochemistry; BNIP3 protein; Brain Ischemia - pathology; Carbamates - pharmacology; Cell Biology; Cell Culture; Cytoplasm; Disease management; Electron microscopy; Hippocampus - pathology; Immunofluorescence; Immunology; Immunoprecipitation; Life Sciences; Lysates; Lysosomes - drug effects; Lysosomes - metabolism; Male; Membrane Fusion - drug effects; Membrane potential; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitophagy; Mitophagy - drug effects; Neurons - drug effects; Neurons - metabolism; Neurons - ultrastructure; Neuroprotection; Neuroprotective Agents - pharmacology; Parkin protein; Phagocytosis; Phosphorylation - drug effects; Protein expression; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats, Sprague-Dawley; Synapses - drug effects; Synapses - pathology; Synapses - ultrastructure; TOR Serine-Threonine Kinases - metabolism; Western blotting