Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma

• Published in: The FASEB journal Vol. 20; no. 8; pp. 1188 - 1190
• Main Authors: Pscherer, Armin, Schliwka, Julia, Wildenberger, Kathrin, Mincheva, Antoaneta, Schwaenen, Carsten, Döhner, Hartmut, Stilgenbauer, Stephan, Lichter, Peter
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 01.06.2006
• Subjects: Cell Line, Tumor; Cell Proliferation; Chromosomes, Artificial, Bacterial; Gene Expression Regulation; Gene Targeting - methods; Genes, Tumor Suppressor; Genome, Human; Humans; Interferons - metabolism; Lymphoma, Mantle-Cell - genetics; Lymphoma, Mantle-Cell - metabolism; Oncogenes; RNA Interference; Transgenes

A broad range of malignant diseases, such as mantle cell lymphoma (MCL), is associated with complex genomic alterations, demanding multimodal functional testing of candidate genes. To assess such candidate disease genes, we have developed a bidirectional targeted transgenesis tool, which allows well...