In vitro transformation of chlorogenic acid by human gut microbiota

• Published in: Molecular nutrition & food research Vol. 58; no. 5; pp. 1122 - 1131
• Main Authors: Tomas‐Barberan, Francisco, García‐Villalba, Rocío, Quartieri, Andrea, Raimondi, Stefano, Amaretti, Alberto, Leonardi, Alan, Rossi, Maddalena
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag GmbH & Co. KGaA 01.05.2014; Blackwell Publishing Ltd; Wiley
• Subjects: absorption; Bifidobacterium; Bifidobacterium - metabolism; Bifidobacterium animalis; Bioconversion; Biological and medical sciences; biotransformation; Chlorogenic acid; Chlorogenic Acid - metabolism; Chromatography, High Pressure Liquid; colon; diet; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - microbiology; Humans; hydrogenation; Hydrolysis; In Situ Hybridization, Fluorescence; Intestinal microbiota; intestinal microorganisms; Male; metabolism; metabolites; Microbiota; phenolic acids; phenylacetic acid; Probiotic; Probiotics; quinic acid; small intestine; Tandem Mass Spectrometry; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Probiotic; Bifidobacterium; Nutrition; Phenolic acid; Eubacteria; Gut; Bifidobacteriaceae; Microflora; Bioconversion; Chlorogenic acid; In vitro; Actinobacteridae; Biotransformation; Intestinal microbiota; Actinobacteria; Bacteria; Bifidobacteriales

SCOPE: Chlorogenic acid (3‐O‐caffeoyl‐quinic acid, C‐QA), the caffeic ester of quinic acid, is one of the most abundant phenolic acids in Western diet. The majority of C‐QA escapes absorption in the small intestine and reaches the colon, where the resident microbiota transforms it into several metab...