Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma

• Published in: Translational oncology Vol. 42; p. 101867
• Main Authors: Kgokolo, Mahlatse C.M., Malinga, Nonkululeko Z., Steel, Helen C., Meyer, Pieter W.A., Smit, Teresa, Anderson, Ronald, Rapoport, Bernardo L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2024; Neoplasia Press; Elsevier
• Subjects: Arginase 1; Basal cell carcinoma; CTLA-4 antigen; PD-L1; Regulatory T-lymphocytes; Transforming growth factor-β1; PD-L1; Arginase 1; CTLA-4 antigen; Basal cell carcinoma; Regulatory T-lymphocytes; Transforming growth factor-β1

The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells (n = 7) in a cohort of patients with basal cell carcinoma (BCC, n = 40) and a group of healthy control subjects (n...