Concentration‐effect relationships of two infusion rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of side‐effects in healthy subjects

• Published in: British journal of clinical pharmacology Vol. 51; no. 5; pp. 423 - 428
• Main Authors: De Visser, S. J., Van Gerven, J. M. A., Schoemaker, R. C., Cohen, A. F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.05.2001; Blackwell Science; Blackwell Science Inc
• Subjects: Adult; Antihypertensive agents; Antihypertensive Agents - adverse effects; Antihypertensive Agents - pharmacokinetics; Antihypertensive Agents - pharmacology; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography - drug effects; Female; Heart Rate - drug effects; Humans; hypertension; Infusions, Intravenous; Male; Medical sciences; Oxazoles - adverse effects; Oxazoles - pharmacokinetics; Oxazoles - pharmacology; Pain Measurement - drug effects; pharmacodynamics; pharmacokinetics; Pharmacokinetics/Pharmacodynamics; Pharmacology. Drug treatments; rate; Rilmenidine; Saccades - drug effects; Salivary Glands - drug effects; Salivary Glands - physiology; Human; Pharmacokinetic pharmacodynamic relationship; Agonist; Intravenous administration; Healthy subject; Rilmenidine; Velocity; Saccadic eye movement; Activity concentration relation; I1 Imidazoline receptor; Perfusion; Antihypertensive agent; Arterial pressure; Application method; Pharmacokinetics

Aims  The aim of this study was to compare the effect profiles of i.v. administered rilmenidine aimed at the same target plasma concentration, but attained with different rates. Methods  The study was placebo‐controlled, randomized, double‐blind, double‐dummy, three‐way, cross‐over in nine healthy v...