The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension

• Published in: British journal of clinical pharmacology Vol. 48; no. 3; pp. 460 - 463
• Main Authors: DAWES, M, BRETT, S. E, CHOWIENCZYK, P. J, MANT, T. G. K, RITTER, J. M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.1999; Blackwell Science; Blackwell Science Inc
• Subjects: Adolescent; Adult; Aged; Antihypertensive agents; Benzopyrans - pharmacology; Benzopyrans - therapeutic use; Biological and medical sciences; Cardiovascular system; Drug Interactions; Enzyme Inhibitors - pharmacology; essential hypertension; Ethanolamines - pharmacology; Ethanolamines - therapeutic use; Female; Forearm; forearm resistance vasculature; Humans; Hypertension - physiopathology; Male; Medical sciences; Middle Aged; Nebivolol; nitric oxide; N G‐monomethyl‐l‐arginine; omega-N-Methylarginine - pharmacology; Original; Pharmacology. Drug treatments; Regional Blood Flow - drug effects; Vasodilation; Vasodilator Agents - pharmacology; Vasodilator Agents - therapeutic use; Human; Hypertension; Nebivolol; Cardiovascular disease; Sympathomimetic; Vasodilation; Blood flow; Dose activity relation; Multiple dose; Chemotherapy; Forearm; β1-Adrenergic receptor; Treatment; Nitric oxide; Blood vessel; Antihypertensive agent; Clinical trial; Intraarterial administration; Circulatory system; Antagonist

Aims Brachial artery administration of nebivolol increases forearm blood flow in normotensive subjects through activation of the l‐arginine/NO pathway. The aim of the present study was to investigate the effect of brachial artery administration of nebivolol in subjects with essential hypertension. M...