Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models

• Published in: Nature communications Vol. 13; no. 1; pp. 5613 - 11
• Main Authors: Baghdasaryan, Ani, Wang, Feifei, Ren, Fuqiang, Ma, Zhuoran, Li, Jiachen, Zhou, Xueting, Grigoryan, Lilit, Xu, Chun, Dai, Hongjie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/245/2226; 631/61/350/2093; 631/67/2321; 639/925/357/354; 692/308/1426; Animal models; Biocompatibility; Biopsy; Breast cancer; Colon; Colon cancer; Colorectal cancer; Fluorescence; Fluorescent indicators; Fluoroscopic imaging; Gold; Humanities and Social Sciences; Lymph nodes; Lymphatic system; Medical imaging; Metastases; Molecular clusters; Mouse devices; multidisciplinary; Nanoclusters; Phosphorylcholine; Radioactive tracers; Science; Science (multidisciplinary); Serum proteins; Tracers; Tumors

Sentinel lymph node imaging and biopsy is important to clinical assessment of cancer metastasis, and novel non-radioactive lymphographic tracers have been actively pursued over the years. Here, we develop gold molecular clusters (Au 25 ) functionalized by phosphorylcholine (PC) ligands for NIR-II (1...