Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome

• Published in: Critical care medicine Vol. 47; no. 8; p. 1089
• Main Authors: Rogers, Angela J, Guan, Jiazhen, Trtchounian, Anna, Hunninghake, Gary M, Kaimal, Rajani, Desai, Manisha, Kozikowski, Lori-Ann, DeSouza, Lesley, Mogan, Susan, Liu, Kathleen D, Matthay, Michael A, Steingrub, Jay, Wheeler, Art, Yoon, Joo Heon, Nakahira, Kiichi, Choi, Augustine M, Baron, Rebecca M
• Format: Journal Article
• Language: English
• Published: United States 01.08.2019
• Subjects: Acute Lung Injury - immunology; Adult; Female; Humans; Intensive Care Units; Interleukin-18 - blood; Male; Middle Aged; Pulmonary Alveoli - physiopathology; Respiratory Distress Syndrome - immunology; Respiratory Distress Syndrome - mortality; Retrospective Studies; Sepsis - blood; Sepsis - mortality

A high plasma level of inflammasome mediator interleukin-18 was associated with mortality in observational acute respiratory distress syndrome cohorts. Statin exposure increases both inflammasome activation and lung injury in mouse models. We tested whether randomization to statin therapy correlated...