The effects of low-dose epinephrine infusion on spleen size, central and hepatic circulation and circulating platelets

• Published in: Clinical physiology and functional imaging Vol. 33; no. 1; pp. 30 - 37
• Main Authors: Bakovic, Darija, Pivac, Nediljko, Eterovic, Davor, Breskovic, Toni, Zubin, Petra, Obad, Ante, Dujic, Zeljko
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.01.2013; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Biological and medical sciences; Blood Flow Velocity - drug effects; Blood Platelets - drug effects; Blood Pressure - drug effects; Cardiac Output - drug effects; Circulating; Circulation; Counting; Epinephrine; Epinephrine - administration & dosage; Erythrocyte Indices; Fundamental and applied biological sciences. Psychology; Heart Rate - drug effects; Hepatic Veins - diagnostic imaging; Hepatic Veins - drug effects; Humans; Infusion; Infusions, Intravenous; large platelets; Leukocyte Count; Liver Circulation - drug effects; Male; mean platelet volume; Multipurpose vehicles; Organ Size - drug effects; Platelet Count; Platelets; risk of thrombosis; Spleen; Spleen - diagnostic imaging; Spleen - drug effects; spleen volume; sympathetic stimulation; Sympathomimetics - administration & dosage; Time Factors; Ultrasonography; Vascular Resistance - drug effects; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Epinephrine; Spleen; sympathetic stimulation; risk of thrombosis; Low dose; spleen volume; Cardiovascular disease; Stimulation; Catecholamine; Sympathetic nervous system; Thrombosis; Vascular disease; Vertebrata; Platelet; Mammalia; Autonomic nervous system; Neurotransmitter; large platelets; mean platelet volume

Summary In several conditions associated with adrenergic stimulation, an increase in peripheral count of larger platelets has been observed, but the mechanism remained elusive. Larger platelets have greater prothrombotic potential and increase the risk of acute thrombotic events. The human spleen re...