Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells

• Published in: The FASEB journal Vol. 25; no. 11; p. 3873
• Main Authors: Rogel, Micah R, Soni, Pritin N, Troken, James R, Sitikov, Albert, Trejo, Humberto E, Ridge, Karen M
• Format: Journal Article
• Language: English
• Published: United States 01.11.2011
• Subjects: Animals; Cell Line; Cell Movement - drug effects; Cell Proliferation - drug effects; Humans; Male; Pulmonary Alveoli - cytology; Rats; Smad Proteins - physiology; Transforming Growth Factor beta1 - physiology; Vimentin - biosynthesis; Vimentin - physiology; Wound Healing - physiology

The physiological and pathophysiological implications of the expression of vimentin, a type III intermediate filament protein, in alveolar epithelial cells (AECs) are unknown. We provide data demonstrating that vimentin is regulated by TGFβ1, a major cytokine released in response to acute lung injur...