Pelvic floor disorders: linking genetic risk factors to biochemical changes

• Published in: BJU international Vol. 108; no. 8; pp. 1240 - 1247
• Main Authors: Campeau, Lysanne, Gorbachinsky, Ilya, Badlani, Gopal H., Andersson, Karl Erik
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011; Wiley-Blackwell
• Subjects: Biological and medical sciences; collagen; Collagen - genetics; Collagen - metabolism; elastin; Elastin - genetics; Elastin - metabolism; Extracellular Matrix - metabolism; Female; Genetic Predisposition to Disease; Humans; matrix metalloproteinase; Matrix Metalloproteinases; Medical sciences; Nephrology. Urinary tract diseases; Pelvic Floor - pathology; pelvic floor disorder; pelvic organ prolapse; Pelvic Organ Prolapse - genetics; Pelvic Organ Prolapse - metabolism; Risk Factors; stress urinary incontinence; Urinary Incontinence, Stress - genetics; Urinary Incontinence, Stress - metabolism; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Nephrology; Metalloendopeptidases; Biochemistry; pelvic floor disorder; Genetic determinism; Epidemiology; pelvic organ prolapse; Urology; Voiding dysfunction; Pelvic cavity; Urinary system disease; stress urinary incontinence; Enzyme; Elastin; Glycoprotein; Urinary tract disease; Prolapse; Genetic disease; Prolapsus; Peptidases; Pelvic floor; Collagen; Risk factor; Hydrolases; matrix metalloproteinase; Bladder disease; Urinary stress incontinence; Organ

What's known on the subject? and What does the study add? Pelvic floor disorders are associated with altered biochemical composition and structure of pelvic tissue. Epidemiological studies have postulated a genetic contribution to pelvic floor disorders. Certain biochemical changes can be expla...