Positron Emission Tomography Imaging of Mu- and Delta-Opioid Receptor Binding in Alcohol-Dependent and Healthy Control Subjects

• Published in: Alcoholism, clinical and experimental research Vol. 35; no. 12; pp. 2162 - 2173
• Main Authors: Weerts, Elise M., Wand, Gary S., Kuwabara, Hiroto, Munro, Cynthia A., Dannals, Robert F., Hilton, John, Frost, J. James, McCaul, Mary E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2011; Wiley
• Subjects: Abstinence; Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcoholism; Alcoholism - diagnostic imaging; Alcoholism - metabolism; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Brain Imaging; Carfentanil; Case-Control Studies; Female; Humans; Male; Medical sciences; Middle Aged; Naltrindole; Positron-Emission Tomography - methods; Protein Binding; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Opioid, delta - metabolism; Receptors, Opioid, mu - metabolism; Toxicology; Young Adult; Human; Binding; Poison withdrawal; Alcoholism; Central nervous system; Brain Imaging; δ Opioid receptor; Abstinence; Encephalon; Alcoholic beverage; Carfentanil; Dependence; Disintoxication; Medical imagery; Naltrindole; Positron emission tomography; Emission tomography

Background:  The endogenous opioid system plays a significant role in alcohol dependence. The goal of the current study was to investigate regional brain mu‐opioid receptor (MOR) and delta‐opioid receptor (DOR) availability in recently abstinent alcohol‐dependent and age‐matched healthy control men...