The t-PA-encapsulated PLGA nanoparticles shelled with CS or CS-GRGD alter both permeation through and dissolving patterns of blood clots compared with t-PA solution: An in vitro thrombolysis study

• Published in: Journal of biomedical materials research. Part A Vol. 91A; no. 3; pp. 753 - 761
• Main Authors: Wang, Shoei-Shen, Chou, Nai-Kuan, Chung, Tze-Wen
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2009
• Subjects: Animals; Biomedical materials; Blood Coagulation - drug effects; Cattle; Chitosan - chemistry; Dissolution; dissolving patterns of clots; Drug Delivery Systems; Encapsulation; Humans; In Vitro Techniques; In vitro testing; in vitro thrombolysis model; Lactic Acid - chemistry; Mathematical models; Nanoparticles - chemistry; Nanotechnology - methods; Oligopeptides - chemistry; Penetration; Permeation; permeation through patterns; PLGA/CS-GRGD NPs; Polyglycolic Acid - chemistry; Recombinant Proteins - therapeutic use; Spectroscopy, Fourier Transform Infrared; Surgical implants; Thrombolytic Therapy - methods; Tissue Plasminogen Activator - chemistry

Accelerated thrombolysis by pressure‐driven permeation has been demonstrated in in vitro and in vivo animal models by using plasminogen activators (PAs) encapsulated liposomes or PEG microparticles. Recent reports have also described acceleration of thrombolysis using tissue type PA (t‐PA) encapsula...