The human and murine hematopoietic stem cell niches: are they comparable?

Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self‐renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guided by mouse studies. However, parallel studies with...

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Published inAnnals of the New York Academy of Sciences Vol. 1370; no. 1; pp. 55 - 64
Main Authors van Pel, Melissa, Fibbe, Willem E., Schepers, Koen
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.04.2016
Wiley Subscription Services, Inc
Subjects
Animals
Cell Differentiation - physiology
coculture
Genes
Hematopoietic Stem Cell Transplantation
hematopoietic stem cells
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
mesenchymal stromal cell
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mice
Rodents
stem cell niche
Stem Cell Niche - physiology
Stem cells
xenograft model
Xenograft Model Antitumor Assays
stem cell niche
xenograft model
coculture
mesenchymal stromal cell
hematopoietic stem cells
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Abstract Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self‐renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guided by mouse studies. However, parallel studies with human subjects, tissues, and cells, in combination with xenotransplantation experiments in immunodeficient mice, have contributed to our increased understanding of the human HSC niche. Here, we summarize our current knowledge of the various specialized subsets of both stromal and hematopoietic cells that support HSCs through cell–cell interactions and secreted factors, and the many parallels between the murine and human HSC niches. Furthermore, we discuss recent technological advances that are likely to improve our understanding of the human HSC niche, a better understanding of which may allow further identification of unique molecular and cellular pathways in the HSC niche. This information may help to further improve the outcome of HSC transplantation and refine the treatment of hematopoietic diseases.
AbstractList Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self-renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guided by mouse studies. However, parallel studies with human subjects, tissues, and cells, in combination with xenotransplantation experiments in immunodeficient mice, have contributed to our increased understanding of the human HSC niche. Here, we summarize our current knowledge of the various specialized subsets of both stromal and hematopoietic cells that support HSCs through cell-cell interactions and secreted factors, and the many parallels between the murine and human HSC niches. Furthermore, we discuss recent technological advances that are likely to improve our understanding of the human HSC niche, a better understanding of which may allow further identification of unique molecular and cellular pathways in the HSC niche. This information may help to further improve the outcome of HSC transplantation and refine the treatment of hematopoietic diseases.Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self-renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guided by mouse studies. However, parallel studies with human subjects, tissues, and cells, in combination with xenotransplantation experiments in immunodeficient mice, have contributed to our increased understanding of the human HSC niche. Here, we summarize our current knowledge of the various specialized subsets of both stromal and hematopoietic cells that support HSCs through cell-cell interactions and secreted factors, and the many parallels between the murine and human HSC niches. Furthermore, we discuss recent technological advances that are likely to improve our understanding of the human HSC niche, a better understanding of which may allow further identification of unique molecular and cellular pathways in the HSC niche. This information may help to further improve the outcome of HSC transplantation and refine the treatment of hematopoietic diseases.
Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self‐renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guided by mouse studies. However, parallel studies with human subjects, tissues, and cells, in combination with xenotransplantation experiments in immunodeficient mice, have contributed to our increased understanding of the human HSC niche. Here, we summarize our current knowledge of the various specialized subsets of both stromal and hematopoietic cells that support HSCs through cell–cell interactions and secreted factors, and the many parallels between the murine and human HSC niches. Furthermore, we discuss recent technological advances that are likely to improve our understanding of the human HSC niche, a better understanding of which may allow further identification of unique molecular and cellular pathways in the HSC niche. This information may help to further improve the outcome of HSC transplantation and refine the treatment of hematopoietic diseases.
Author Schepers, Koen
van Pel, Melissa
Fibbe, Willem E.
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  surname: van Pel
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Keywords stem cell niche
xenograft model
coculture
mesenchymal stromal cell
hematopoietic stem cells
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Snippet Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self‐renewal and their development into all...
Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self-renewal and their development into all...
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SubjectTerms Animals
Cell Differentiation - physiology
coculture
Genes
Hematopoietic Stem Cell Transplantation
hematopoietic stem cells
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
mesenchymal stromal cell
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mice
Rodents
stem cell niche
Stem Cell Niche - physiology
Stem cells
xenograft model
Xenograft Model Antitumor Assays
Title The human and murine hematopoietic stem cell niches: are they comparable?
URI https://api.istex.fr/ark:/67375/WNG-457XRD0C-L/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnyas.12994
https://www.ncbi.nlm.nih.gov/pubmed/26713726
https://www.proquest.com/docview/1797263928
https://www.proquest.com/docview/1795878776
https://www.proquest.com/docview/1808696631
Volume 1370
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