Role of Nrf2 in Cancer Photodynamic Therapy: Regulation of Human ABC Transporter ABCG2

• Published in: Journal of pharmaceutical sciences Vol. 102; no. 9; pp. 3058 - 3069
• Main Authors: Ishikawa, Toshihisa, Kajimoto, Yoshinaga, Sun, Wei, Nakagawa, Hiroshi, Inoue, Yutaka, Ikegami, Yoji, Miyatake, Shin-Ichi, Kuroiwa, Toshihiko
• Format: Journal Article
• Language: English
• Published: Hoboken Elsevier Inc 01.09.2013; Wiley Subscription Services, Inc., A Wiley Company; Elsevier Limited
• Subjects: ABC transporters; aminolevulinic acid (ALA); Animals; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; cancer; gefitinib; Humans; metabolism; mRNA; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nrf2; oxidative stress; Photochemotherapy; Polymorphism, Single Nucleotide; porphyrin; Porphyrins - metabolism; Reactive Oxygen Species - metabolism; single nucleotide polymorphism (SNP); Transcriptional Activation; porphyrin; Nrf2; aminolevulinic acid (ALA); single nucleotide polymorphism (SNP); ABC transporters; cancer; gefitinib; metabolism; mRNA; oxidative stress

Photodynamic therapy (PDT) is a recently developed anticancer treatment that utilizes the generation of singlet oxygen and other reactive oxygen species in cancer tissue. In response to oxidative stress, NF-E2-related transcription factor (Nrf2) encoded by the NFE2L2 gene plays a key role in transcr...