Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

• Published in: Journal of lipid research Vol. 60; no. 1; pp. 9 - 18
• Main Authors: Skotland, Tore, Hessvik, Nina P., Sandvig, Kirsten, Llorente, Alicia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2019; The American Society for Biochemistry and Molecular Biology; Elsevier
• Series: Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions
• Subjects: Animals; cellular membranes; Ether - chemistry; Exosomes - metabolism; extracellular vesicles; Humans; lipidomics; Phosphatidylinositols - chemistry; Phosphatidylinositols - metabolism; Thematic Review Series; vesicular transport; cellular membranes; extracellular vesicles; lipidomics; vesicular transport

Exosomes are a type of extracellular vesicle released from cells after fusion of multivesicular bodies with the plasma membrane. These vesicles are often enriched in cholesterol, SM, glycosphingolipids, and phosphatidylserine. Lipids not only have a structural role in exosomal membranes but also are...