Adenosine enhances acetylcholine receptor channel openings and intracellular calcium 'spiking' in mouse skeletal myotubes

• Published in: Acta Physiologica Vol. 214; no. 4; pp. 467 - 480
• Main Authors: Bernareggi, A., Luin, E., Pavan, B., Parato, G., Sciancalepore, M., Urbani, R., Lorenzon, P.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2015; Wiley Subscription Services, Inc
• Subjects: acetylcholine receptor; adenosine; Adenosine - metabolism; Animals; Calcium - metabolism; Calcium Signaling - physiology; Cells, Cultured; Male; Mice; Mice, Inbred BALB C; Muscle Fibers, Skeletal - metabolism; myotubes; patch clamp; Patch-Clamp Techniques; Receptors, Nicotinic - metabolism; skeletal muscle; adenosine; acetylcholine receptor; myotubes; patch clamp; skeletal muscle

Aims The autocrine activity of the embryonic isoform of the nicotinic acetylcholine receptor is crucial for the correct differentiation and trophism of skeletal muscle cells before innervation. The functional activity of extracellular adenosine and adenosine receptor subtypes expressed in differenti...