Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes

• Published in: The Prostate Vol. 75; no. 5; pp. 463 - 473
• Main Authors: Peek, Elizabeth M., Song, Wang, Zhang, Hanwei, Huang, Jiaoti, Chin, Arnold I.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2015; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Animals; Cell Transformation, Neoplastic - metabolism; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Immunohistochemistry; Lymphocytes, Tumor-Infiltrating - metabolism; Lymphocytes, Tumor-Infiltrating - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; MyD88; Myeloid Differentiation Factor 88 - physiology; NF-kappa B - metabolism; NF-κB; prostate cancer; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Real-Time Polymerase Chain Reaction; Receptors, Androgen - metabolism; Signal Transduction; Toll-like receptors; TRAMP; tumor-infiltrating lymphocytes; Toll-like receptors; NF-κB; tumor-infiltrating lymphocytes; prostate cancer; TRAMP; MyD88

BACKGROUND The influence of pattern recognition receptor (PRR) signaling in the prostate tumor microenvironment remains unclear. Although there may be a role for PRR agonists as adjuvants to therapy, prior evidence suggests tumor promoting as well as tumor inhibiting mechanisms. The purpose of this...