Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 39; no. 5; pp. 902 - 914
• Main Authors: He, Ming, Huang, Tse-Shun, Li, Shuai, Hong, Hsiao-Chin, Chen, Zhen, Martin, Marcy, Zhou, Xin, Huang, Hsi-Yuan, Su, Shu-Han, Zhang, Jiao, Wang, Wei-Ting, Kang, Jian, Huang, Hsien-Da, Zhang, Jin, Chien, Shu, Shyy, John Y.-J
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.05.2019
• Subjects: Animals; Atherosclerosis - genetics; Endothelial Cells; Endothelium, Vascular - metabolism; Epigenomics; Gene Expression Regulation; Histone Code; Humans; Inositol 1,4,5-Trisphosphate Receptors - genetics; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors - genetics; Mice; Nitric Oxide Synthase Type III - metabolism; Promoter Regions, Genetic; Transcription Factors - metabolism; Transcriptional Activation - genetics; Up-Regulation; genome; endothelial cells; nitric oxide; histones; shear stress

OBJECTIVE—The topographical distribution of atherosclerosis in vasculature underscores the importance of shear stress in regulating endothelium. With a systems approach integrating sequencing data, the current study aims to explore the link between shear stress-regulated master transcription factor...