Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions

• Published in: The FASEB journal Vol. 30; no. 2; p. 688
• Main Authors: Roy, Ashbeel, Dakroub, Mouhamed, Tezini, Geisa C S V, Liu, Yin, Guatimosim, Silvia, Feng, Qingping, Salgado, Helio C, Prado, Vania F, Prado, Marco A M, Gros, Robert
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Acetylcholine - metabolism; Animals; Cells, Cultured; Choline O-Acetyltransferase - genetics; Choline O-Acetyltransferase - metabolism; Gene Expression Regulation, Enzymologic - physiology; Heart Failure - metabolism; Humans; Male; Mice; Mice, Knockout; Myocytes, Cardiac - enzymology; Myocytes, Cardiac - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Ventricular Remodeling - physiology; Vesicular Acetylcholine Transport Proteins - genetics; Vesicular Acetylcholine Transport Proteins - metabolism; heart failure; choline acetyltransferase; heart disease; VAChT; nonneuronal acetylcholine

Autonomic dysfunction is a characteristic of cardiac disease and decreased vagal activity is observed in heart failure. Rodent cardiomyocytes produce de novo ACh, which is critical in maintaining cardiac homeostasis. We report that this nonneuronal cholinergic system is also found in human cardiomyo...