Acute and chronic administration of clozapine produces greater proconvulsant actions than haloperidol on focal hippocampal seizures in freely moving rats

• Published in: Synapse (New York, N.Y.) Vol. 29; no. 3; pp. 272 - 278
• Main Authors: Minabe, Yoshio, Watanabe, Kei-Ichiro, Nishimura, Tsutomu, Ashby Jr, Charles R.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.07.1998
• Subjects: Animals; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - pharmacology; clozapine; Clozapine - administration & dosage; Clozapine - pharmacology; epilepsy; haloperidol; Haloperidol - administration & dosage; Haloperidol - pharmacology; hippocampus; Hippocampus - physiopathology; Injections, Intraperitoneal; kindling; Kindling, Neurologic - physiology; Male; Rats; Rats, Wistar; Seizures - etiology; Seizures - physiopathology; Time Factors

In this study, we assessed the effects of the acute (a single injection) and repeated (once daily injections for 21 days) administration of the atypical antipsychotic drug clozapine (1.5, 5, or 15 mg/kg i.p.) and the typical antipsychotic drug haloperidol (0.15, 0.5, and 1.5 mg/kg, i.p.) on hippocam...