Effect of Duodenal Acidification on the Lower Esophageal Sphincter Pressure in the Dog with Special Reference to Related Gastrointestinal Hormones

The role of the duodenum in the regulation of the lower esophageal sphincter pressure was studied in 3 anesthetized dogs with a duodenal fistula by relating the lower esophageal sphincter pressure with plasma gastrin and secretin level during intraduodenal acid infusion test. Instillation of hydroch...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 131; no. 3; pp. 215 - 219
Main Authors HONGO, MICHIO, ISHIMORI, AKIRA, NAGASAKI, AKIO, SATO, TSUNEAKI
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 01.01.1980
Subjects
Animals
Dogs
Duodenum - physiology
Esophagogastric Junction - physiology
gastrin
Gastrins - blood
Hydrochloric Acid - pharmacology
lower esophageal sphincter
motilin
Motilin - blood
Pressure
secretin
Secretin - blood
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Abstract The role of the duodenum in the regulation of the lower esophageal sphincter pressure was studied in 3 anesthetized dogs with a duodenal fistula by relating the lower esophageal sphincter pressure with plasma gastrin and secretin level during intraduodenal acid infusion test. Instillation of hydrochloric acid into the duodenum produced an initial fall followed by a significant and sustained increase of the lower esophageal sphincter pressure. The initial fall of the lower esophageal sphincter pressure was found to correspond to a prompt but transient rise of plasma secretin concentration, while plasma gastrin did not change significantly throughout the experimental period. It is concluded that duodenum may be an important regulator of the lower esophageal sphincter pressure in the dog through secretin and other unknown factors.
AbstractList The role of the duodenum in the regulation of the lower esophageal sphincter pressure was studied in 3 anesthetized dogs with a duodenal fistula by relating the lower esophageal sphincter pressure with plasma gastrin and secretin level during intraduodenal acid infusion test. Instillation of hydrochloric acid into the duodenum produced an initial fall followed by a significant and sustained increase of the lower esophageal sphincter pressure. The initial fall of the lower esophageal sphincter pressure was found to correspond to a prompt but transient rise of plasma secretin concentration, while plasma gastrin did not change significantly throughout the experimental period. It is concluded that duodenum may be an important regulator of the lower esophageal sphincter pressure in the dog through secretin and other unknown factors.
Author SATO, TSUNEAKI
HONGO, MICHIO
NAGASAKI, AKIO
ISHIMORI, AKIRA
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References 9) Lee, K. L., Chey, W. Y., Tai, H. H. & Yajima, H. (1978) Radioimmunoassay of motilin: validation and studies on the relationship between plasma motilin and interdigestive myoelectric activity of the duodenum of dog. Amer. J. dig. Dis., 23, 789-795.
2) Brown, J. C. (1967) Presence of a gastric motor-stimulating property in duodenal extracts. Gastroenterology, 52, 225-229.
7) Dryburgh, J. R. (1977) Thesis: Immunological techniques in the investigation of the physiological functions of the gastric inhibitory polypeptide and motilin. Univ. of Brit. Columbia. Cited by J. C. Brown & J. R. Dryburgh (1978) Isclation of motilin. In: Gut Hormones, edited by S. R. Bloom, Churchill Livingstone, Edinburgh, pp. 327-331
12) Mitznegg, P., Bloom, S. R., Domschke, W., Wünsch, E. & Demling, L. (1976) Release of motilin after duodenal acidification. Lancet, 1, 888-889.
14) Nagasaki, A., Ishimori, A., Masamune, O. & Yamagata, S. (1977) Response of lower esophageal sphincter pressure to beef soup or AOC-tetrapeptide stimulation in esophagitis. Tohoku J. exp. Med., 121, 91-97.
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6) Domschke, W., Lux, G., Bloom, S. R., Wünsch, E., Demling, L., Mitznegg, P. & Röesh, S. (1976) Endogenous motilin and lower esophageal sphincter pressure in man: clue to an association. Acta hepatogastroenterol. 23, 274-275.
13) Mossa, A. R., Hall, A. W., Hughes, R. G. Maraldi, A., Mossa, D. E. & Skinner, D. B. (1978) Effect of gastrointestinal hormone infusion on lower esophageal competence of Rheusus monkeys. Brit. J. Surg., 65, 499-504.
3) Castell, D. O. (1978) Gastrin and lower esophageal sphincter tone. Arch. intern. Med., 138, 196.
8) Eckardt, V. F., Grace, N. D., Osborne, M. P. & Fischer, J. E. (1978) Lower esophageal sphincter pressure and serum gastrin levels after mapped antrectomy. Arch. intern. Med., 138, 242-245
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1) Bayliss. W. M. & Starling, E. H. (1902) The mechanism of pancreatic secretion. J. Physiol., 28, 325-353.
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SubjectTerms Animals
Dogs
Duodenum - physiology
Esophagogastric Junction - physiology
gastrin
Gastrins - blood
Hydrochloric Acid - pharmacology
lower esophageal sphincter
motilin
Motilin - blood
Pressure
secretin
Secretin - blood
Title Effect of Duodenal Acidification on the Lower Esophageal Sphincter Pressure in the Dog with Special Reference to Related Gastrointestinal Hormones
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Volume 131
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