Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles

• Published in: Nature communications Vol. 14; no. 1; p. 2900
• Main Authors: Graca, Flavia A, Stephan, Anna, Minden-Birkenmaier, Benjamin A, Shirinifard, Abbas, Wang, Yong-Dong, Demontis, Fabio, Labelle, Myriam
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 22.05.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Angiogenesis; Animals; Chemokines; Chemotactic factors; Depletion; Hemostasis; Hemostatics; Infiltration; Inflammation; Injuries; Leukocytes (neutrophilic); Male; Mice; Muscle strength; Muscle, Skeletal - physiology; Muscles; Musculoskeletal system; Neutrophil Infiltration; Neutrophils; Neutrophils - physiology; Platelets; Recruitment; Regeneration; Signaling; Skeletal muscle

Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but whether platelets promote regeneration beyond their role in hemostasis remains unexplored. Here, we find that sign...