A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs’ Susceptibility

• Published in: Viruses Vol. 16; no. 12; p. 1813
• Main Authors: Yamada, Souichi, Harada, Shizuko, Fujii, Hikaru, Kinoshita, Hitomi, Nguyen, Phu Hoang Anh, Shibamura, Miho, Yoshikawa, Tomoki, Kawahara, Madoka, Ebihara, Hideki, Saijo, Masayuki, Fukushi, Shuetsu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Acyclovir; Acyclovir - pharmacology; Acyclovir - therapeutic use; Animals; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Antiviral drugs; Chemicals; Chlorocebus aethiops; Cloning; Disease resistance; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Viral - genetics; E coli; Gene mutations; Genes; Genes, Viral; Genetic aspects; Genomes; Health aspects; Herpes simplex; Herpes Simplex - drug therapy; Herpes Simplex - virology; Herpes simplex virus; herpes simplex virus type 1 (HSV-1); Herpes viruses; Herpesvirus 1, Human - drug effects; Herpesvirus 1, Human - genetics; Humans; ICP8 protein; Infections; Kinases; Microbial Sensitivity Tests; Missense mutation; Mutagenesis; Mutants; Mutation; Mutation, Missense; Penicillin; Polyclonal antibodies; Proteins; Thymidine kinase; Thymidine Kinase - genetics; Thymidine Kinase - metabolism; UL29; Varicella; Vero Cells; Viral Proteins - genetics; Viral Proteins - metabolism; Whole genome sequencing; Japan; St Louis Missouri; United Kingdom > UK; United States > US; Germany; UL29; acyclovir; drug resistance; herpes simplex virus type 1 (HSV-1)

Herpes simplex virus type 1 (HSV-1) acyclovir (ACV) resistance is acquired by mutations in the viral thymidine kinase (TK) or DNA polymerase (DNApol) genes. We previously obtained an ACV-resistant clone (HSV-1_VZV_TK_clone α) by sequential passages of HSV-1_VZV-TK, a recombinant virus which lacked i...