Dental pulp cells derived from permanent teeth express higher levels of R-cadherin than do deciduous teeth: Implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells

• Published in: Archives of oral biology Vol. 57; no. 1; pp. 44 - 51
• Main Authors: Takahashi, Noriko, Chosa, Naoyuki, Hasegawa, Tomokazu, Nishihira, Soko, Okubo, Naoto, Takahashi, Mamoru, Sugiyama, Yoshiki, Tanaka, Mitsuro, Ishisaki, Akira
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2012
• Subjects: Advanced Basic Science; Cadherins - metabolism; Cell adhesion molecules; Cell Adhesion Molecules - metabolism; Cell Culture Techniques; Cell Differentiation; Child; Dental Pulp - cytology; Dental Pulp - metabolism; Dental pulp cells; Dentistry; Dentition, Permanent; Flow Cytometry; Gene Expression Profiling; Humans; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Microscopy, Confocal; Multipotency; R-cadherin; Real-Time Polymerase Chain Reaction; RNA - analysis; Tooth, Deciduous - cytology; Tooth, Deciduous - metabolism; Multipotency; R-cadherin; Dental pulp cells; Cell adhesion molecules; Mesenchymal stem cells

Abstract Objectives The aim of this study was to characterize the expression status of cadherins in dental pulp-derived mesenchymal progenitor/stem cells from deciduous and permanent teeth, and to determine how cadherins affect the multipotency of the progenitor/stem cells. Materials and methods We...