Programming cytomegalovirus as an HIV vaccine

• Published in: Trends in immunology Vol. 44; no. 4; pp. 287 - 304
• Main Authors: Picker, Louis J., Lifson, Jeffrey D., Gale, Michael, Hansen, Scott G., Früh, Klaus
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2023
• Subjects: AIDS Vaccines; Animals; CD8-Positive T-Lymphocytes; Cytomegalovirus; Cytomegalovirus Infections; HIV vaccine; immune programming; Simian Acquired Immunodeficiency Syndrome - prevention & control; Simian Immunodeficiency Virus; SIV replication arrest; immune programming; SIV replication arrest; cytomegalovirus; HIV vaccine

Non-human primate (NHP) cytomegaloviruses (CMVs) can be genetically modified to induce unconventional CD8+ T cell responses that target epitopes presented by MHC-II and MHC-E; the latter is an MHC-Ib molecule with limited polymorphism, primarily known for regulating natural killer (NK) cell reactivi...