MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein

• Published in: Viruses Vol. 16; no. 12; p. 1935
• Main Authors: Okura, Takashi, Takahashi, Tatsuki, Kameya, Taichi, Mizukoshi, Fuminori, Nakai, Yusuke, Kakizaki, Masatoshi, Nishi, Mayuko, Otsuki, Noriyuki, Kimura, Hirokazu, Miyakawa, Kei, Shirato, Kazuya, Kamitani, Wataru, Ryo, Akihide
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: A549 Cells; Antibodies; Antiviral drugs; Apoptosis; Cell Line; Cell survival; Cloning; Control; Degradation; Disease transmission; Genomes; Health aspects; HEK293 Cells; Host-Pathogen Interactions; Humans; Hydrophobicity; Influenza; MARCH8; Physiological aspects; Plasmids; Protein expression; Proteins; Proteolysis; Replication; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - metabolism; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Virus, Human - genetics; Respiratory Syncytial Virus, Human - metabolism; Respiratory Syncytial Virus, Human - physiology; small hydrophobic protein; Ubiquitin; Ubiquitin - metabolism; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Vaccines; Viral infections; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication; Viruses; Japan; United States > US; apoptosis; MARCH8; ubiquitination; respiratory syncytial virus; small hydrophobic protein

Numerous host factors function as intrinsic antiviral effectors to attenuate viral replication. MARCH8 is an E3 ubiquitin ligase that has been identified as a host restriction factor that inhibits the replication of various viruses. This study elucidated the mechanism by which MARCH8 restricts respi...