Identification of a DOCK180-related Guanine Nucleotide Exchange Factor That Is Capable of Mediating a Positive Feedback Activation of Cdc42

• Published in: The Journal of biological chemistry Vol. 281; no. 46; pp. 35253 - 35262
• Main Authors: Lin, Qiong, Yang, Wannian, Baird, Daniel, Feng, Qiyu, Cerione, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.11.2006; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; cdc42 GTP-Binding Protein - chemistry; cdc42 GTP-Binding Protein - metabolism; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Feedback, Physiological; Gene Expression Regulation; Guanine Nucleotide Exchange Factors - chemistry; Guanine Nucleotide Exchange Factors - metabolism; Mice; Molecular Sequence Data; Protein Binding; rac GTP-Binding Proteins - chemistry

Cdc42, a member of the Rho subfamily of small GTPases, influences a wide range of activities including the establishment of cell polarity, migration, and the regulation of cell growth and differentiation. Here we describe the identification of an ∼220-kDa protein that formed a stable complex with ac...