Age, β-endorphin, and sex dependent effects of maternal separation on locomotor activity, anxiety-like behavior, and alcohol reward

• Published in: Frontiers in behavioral neuroscience Vol. 17; p. 1155647
• Main Authors: Scopano, Madison R., Jones, Holly E., Stea, Sam G., Freeman, Maya Z., Grisel, Judith E.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 05.04.2023; Frontiers Media S.A
• Subjects: adolescent; Adolescents; Alcohol; Animal models; Anxiety; Anxiety disorders; Behavior; Cameras; Children; conditioned place preference; Drug use; early life stress; Endorphins; EtOH reinforcement; Females; Gender differences; Genotypes; Locomotor activity; Maternal behavior; Mental disorders; Narcotics; Neuroscience; opioid; Place preference conditioning; Self-medication; Sex; sex differences; Stress; Stress response; Substance use; Teenagers; Weaning; development; conditioned place preference; opioid; adolescent; EtOH reinforcement; early life stress; sex differences; adverse childhood experiences

Childhood adversity is pervasive and linked to numerous disadvantages in adulthood, including physical health problems, mental illness, and substance use disorders. Initial sensitivity to the rewarding effects of alcohol predicts the risk of developing an alcohol use disorder, and may be linked to d...