Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 299; no. 5; pp. H1318 - H1327
• Main Authors: Delaney, Erin P., Greaney, Jody L., Edwards, David G., Rose, William C., Fadel, Paul J., Farquhar, William B.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2010
• Subjects: Aging - physiology; Baroreflex - physiology; Blood Pressure - physiology; Cardiovascular Physiological Phenomena; Case-Control Studies; Exercise; Exercise - physiology; Female; Hand Strength - physiology; Hands; Human subjects; Humans; Hypertension; Hypertension - physiopathology; Male; Middle Aged; Muscle Contraction - physiology; Muscle, Skeletal - innervation; Muscle, Skeletal - physiology; Muscular system; Myocardial Ischemia - epidemiology; Myocardial Ischemia - physiopathology; Risk Factors; Rodents; Sympathetic Nervous System - physiology

Recent animal studies have reported that exercise pressor reflex (EPR)-mediated increases in blood pressure are exaggerated in hypertensive (HTN) rodents. Whether these findings can be extended to human hypertension remains unclear. Mean arterial pressure (MAP), muscle sympathetic nerve activity (MS...