Connecting Mitochondria, Metabolism, and Stem Cell Fate

• Published in: Stem cells and development Vol. 24; no. 17; pp. 1957 - 1971
• Main Authors: Wanet, Anaïs, Arnould, Thierry, Najimi, Mustapha, Renard, Patricia
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.09.2015
• Subjects: Adult Stem Cells - cytology; Animals; Cell Differentiation - physiology; Cell Proliferation - physiology; Comprehensive Reviews; Energy Metabolism - physiology; Humans; Mitochondria - metabolism; Pluripotent Stem Cells - cytology

As sites of cellular respiration and energy production, mitochondria play a central role in cell metabolism. Cell differentiation is associated with an increase in mitochondrial content and activity and with a metabolic shift toward increased oxidative phosphorylation activity. The opposite occurs d...