Rewriting Viral Fate: Epigenetic and Transcriptional Dynamics in KSHV Infection

• Published in: Viruses Vol. 16; no. 12; p. 1870
• Main Authors: Han, Chunyan, Niu, Danping, Lan, Ke
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Acetylation; Castleman's disease; Chromatin remodeling; Conformation; DNA biosynthesis; DNA Methylation; DNA viruses; Effusion; Epigenesis, Genetic; epigenetic modifications; Epigenetics; Gene expression; Gene Expression Regulation, Viral; Gene regulation; Gene silencing; Genetic aspects; Genomes; Herpes viruses; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - physiology; Herpesviruses; Histones; Histones - metabolism; Host-Pathogen Interactions - genetics; Humans; Immunoproliferative diseases; Infections; Kaposi's sarcoma; KSHV; Latency; Latent infection; life cycle; Life cycles; Lymphocytes; MicroRNAs; Molecular modelling; Post-translation; Primary effusion lymphoma; Proteins; Replication; Review; Sarcoma; Sarcoma, Kaposi - genetics; Sarcoma, Kaposi - virology; Transcription activation; Transcription factors; Transcription, Genetic; transcriptional regulation; Tumorigenesis; Viral genetics; Viral infections; Virus Activation - genetics; Virus Latency - genetics; Virus Replication; China; epigenetic modifications; life cycle; KSHV; transcriptional regulation

Kaposi’s sarcoma-associated herpesvirus (KSHV), a γ-herpesvirus, is predominantly associated with Kaposi’s sarcoma (KS) as well as two lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). Like other herpesviruses, KSHV employs two distinct life cyc...