Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 299; no. 1; pp. H62 - H69
• Main Authors: Chen, Xiaoxiao, Sala-Mercado, Javier A, Hammond, Robert L, Ichinose, Masashi, Soltani, Soroor, Mukkamala, Ramakrishna, O'Leary, Donal S
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2010
• Subjects: Animals; Baroreflex; Blood Pressure; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Elasticity; Heart failure; Heart Failure - etiology; Heart Failure - physiopathology; Heart Rate; Models, Cardiovascular; Myocardial Contraction; Time Factors; Veins & arteries; Ventricular Function; Wakefulness

We investigated to what extent maximal ventricular elastance (E(max)) is dynamically controlled by the arterial baroreflex and force-frequency relation in conscious dogs and to what extent these mechanisms are attenuated after the induction of heart failure (HF). We mathematically analyzed spontaneo...