Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB - Liu, Qi; Zhang, Yajuan; Li, Huimin; Gao, Hong; Zhou, Yijie; Luo, Dakui; Shan, Zezhi; Yang, Yufei; Weng, Junyong; Li, Qingguo; Yang, Weiwei; Li, Xinxiang (Cell communication and signaling, 2024)
Keywords: (S)-2,3-epoxysqualene; 5-Fluorouracil; Animals; Antifungal agents; Biosynthesis; Cancer therapies; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell survival; Chemoresistance; Chemoretherapy; Chemotherapy; Cholesterol; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Enzymes; Female; Fluorouracil - pharmacology; Fluorouracil - therapeutic use; Humans; Immunoblotting; Immunoprecipitation; Lymphatic system; Male; Medical prognosis; Medical research; Metabolism; Metabolites; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular modelling; NF-kappa B - metabolism; NF-KappaB Inhibitor alpha - genetics; NF-KappaB Inhibitor alpha - metabolism; NF-κB pathway; NF-κB protein; Patients; Sequence analysis; Squalene; Squalene epoxidase; Squalene Monooxygenase - genetics; Squalene Monooxygenase - metabolism; Survival analysis; Terbinafine; Transducin; Tumors; Ubiquitin-protein ligase; Xenograft Model Antitumor Assays; Chemoretherapy; (S)-2,3-epoxysqualene; Squalene epoxidase; Colorectal cancer; NF-κB pathway