Antibody-dependent CD56+ T cell responses are functionally impaired in long-term HIV-1 infection

• Published in: Retrovirology Vol. 13; no. 1; p. 76
• Main Authors: Fan, Xueying, Zhu, Liyan, Liang, Hua, Xie, Zhe, Huang, Xiangbo, Wang, Shuo, Shen, Tao
• Format: Journal Article
• Language: English
• Published: England BioMed Central 04.11.2016
• Subjects: Adult; Antibody-Dependent Cell Cytotoxicity; CD56 Antigen - immunology; Chronic Disease; Coinfection - virology; Dipeptides - therapeutic use; Disease Progression; GPI-Linked Proteins - metabolism; Hepatitis C - virology; HIV Infections - blood; HIV Infections - immunology; HIV Infections - physiopathology; HIV Infections - virology; HIV Long-Term Survivors; Homosexuality, Male; Humans; Male; Matrix Metalloproteinase Inhibitors - therapeutic use; Natural Killer T-Cells - immunology; Receptors, IgG - metabolism; T-Lymphocyte Subsets - immunology; Time Factors; CD16 cross-linking; MMP inhibitor; CD56+ T; Chronic HIV infection; ADCC; iNKT

Antibody-dependent cellular cytotoxicity (ADCC), which mainly mediated by natural killer (NK) cells, may play a critical role in slowing human immunodeficiency virus type-1 (HIV-1) disease progression and protecting from HIV-1 infection. Besides classic NK cells, CD56+ T cells also have some NK cell...