Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

• Published in: Frontiers in cellular neuroscience Vol. 17; p. 1274459
• Main Authors: Takasu, Keiko, Yawata, Yosuke, Tashima, Ryoichi, Aritomi, Hiroyuki, Shimada, Shinji, Onodera, Tsukasa, Taishi, Teruhiko, Ogawa, Koichi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 08.01.2024; Frontiers Media S.A
• Subjects: Allosteric properties; Amygdala; antidepressant-like effect; Antidepressants; benzodiazepine; Benzodiazepines; Brain research; Cellular Neuroscience; Cellulose; Diazepam; EEG; extrasynaptic GABAA receptor; Interneurons; Laboratory animals; Mental depression; Molecular modelling; Neural networks; neuroactive steroid; Neuromodulation; Neurosteroids; Oscillations; Patients; Postpartum depression; Prefrontal cortex; Pregnanolone; social defeat stress model; Social interaction; Social interactions; Steroid hormones; Steroids; theta activity; γ-Aminobutyric acid A receptors; United States > US; Japan; social defeat stress model; antidepressant-like effect; basolateral amygdala; benzodiazepine; extrasynaptic GABAA receptor; neuroactive steroid; theta activity

The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological symptoms of MDD. Zuranolone (SAGE-217), a neuroact...